Browsing by Subject "Autophagy"
Now showing items 1-11 of 11
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Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy
(2011-09-06)Hepatitis B virus (HBV) is a significant global threat to human health due to its ability to cause chronic infections that can lead to hepatocellular carcinoma (HCC). While the process by which HBV increases the risk of ... -
IDENTIFICATION AND MANIPULATION OF KEY REGULATORS IN LACE PLANT PROGRAMMED CELL DEATH
(2017-06-19)The lace plant (Aponogeton madagascariensis) is an aquatic monocot species that has emerged as a model for studying developmental programmed cell death (PCD). In multicellular eukaryotes, PCD plays vital roles in development ... -
KAPOSI’S SARCOMA-ASSOCIATED HERPESVIRUS PROTEIN, KAPOSIN B INDUCES THE SELECTIVE CATABOLISM OF PROCESSING BODIES
(2019-08-26)Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of the inflammatory endothelial cell (EC) cancer, Kaposi’s Sarcoma (KS). Many inflammatory mRNAs (ARE-mRNAs) are subject to constitutive decay in ... -
Linking PRP4K Cytoplasmic Functions to Tumour Suppression
(2021-06-18)Breast cancer is one of the most common cancers faced by Canadian women today. These carcinomas arise from epithelial cells in mammary tissue, and therefore processes and signaling pathways that regulate tissue homeostasis ... -
LOSS OF PRP4K IMPAIRS AUTOPHAGIC FLUX IN DICTYOSTELIUM DISCOIDEUM AND HUMAN CANCER CELLS
(2023-06-29)The pre-mRNA splicing factor 4 kinase (PRP4K) is a haploinsufficient tumour suppressor conserved from Dictyostelium discoideum (D. discoideum) to humans. Here, we describe the first viable knockout (KO) model in D. discoideum, ... -
QUANTITATIVE MODELLING OF AUTOPHAGY-RELATED PROTEIN DYNAMICS AND CLUSTERING ON PEROXISOME SURFACES
(2015)Autophagy is an important process for the degradation of large cellular substrates, such as organelles. Peroxisomes are membrane-bound organelles ranging in size from 0.1-0.8 μm. There can be hundreds of peroxisomes in a ... -
REGULATION OF INFLAMMATION, LUNG INJURY AND AUTOPHAGY DURING PSEUDOMONAS AERUGINOSA LUNG INFECTION
(2016-04-29)Pseudomonas aeruginosa is an opportunistic bacterial pathogen which causes acute and chronic infections in immune compromised individuals, including cystic fibrosis (CF) patients where it represents the leading cause of ... -
TRANSCRIPTION FACTOR EB REGULATES APOPTOSIS, DNA REPAIR, AND CELL PROLIFERATION IN TRIPLE-NEGATIVE BREAST CANCER CELLS
(2022-05-03)Breast cancer is the leading cause of cancer-related death among women in Canada. Molecular heterogeneity among breast cancer patients dictates survival outcomes and treatment selection, with triple-negative breast cancer ... -
TRANSCRIPTOMIC ANALYSIS IDENTIFIES POTENTIAL REGULATORS INVOLVED IN PROGRAMMED CELL DEATH AND REMODELLING OF LACE PLANT LEAVES (APONOGETON MADAGASCARIENSIS)
(2022-12-06)Programmed cell death (PCD) is a highly controlled, regulated process of deleting cells. Plant PCD is either developmentally regulated or environmentally induced due to biotic or abiotic stress. Leaves of the lace plant ... -
TRPML1 in Autophagy and Neuromuscular Diseases
(2023-08-31)Autophagy is a process that maintains cellular homeostasis and monitors nutrient requirements. During autophagy, cytoplasmic components are engulfed by autophagosomes. These autophagosomes fuse with lysosomes, where lysosomal ... -
TRPML1 REGULATES PROSTATE CANCER CELL PROLIFERATION THROUGH THE MODULATION OF OXIDATIVE STRESS AND CELL CYCLE
(2018-09-04)Prostate cancer (PCa) represents a multifactorial and complex disease affecting thousands of men each year. Although the prognosis of PCa is improving, limitations in early diagnosis pose a challenge for the effective ...