Copeland, Samantha Marie2015-09-232015-09-232015http://hdl.handle.net/10222/63140Should researchers take advantage of unexpected opportunities to make valuable discoveries when these opportunities arise in the context of research involving human participants? The pursuit of knowledge sometimes requires human beings to participate in research as the subjects of study. This is particularly the case when it comes to the pursuit of knowledge about the brain. In this dissertation, I consider the potential value of serendipitous discoveries in the context of clinical research involving humans, with a narrow focus on deep brain stimulation (DBS) – a technology that enables clinician-researchers to access and manipulate the living human brain. Along the way, I accomplish three goals. First, I provide an account of serendipitous discovery in science. Serendipity consists of three elements—chance, sagacity and a valued outcome—that come together in a single process of discovery. Second, I apply my analysis to a case of potential serendipity in early phase medical research involving humans. Third, I explore the epistemological and ethical implications of both the analysis and its application. Serendipitous discoveries, for instance, are made by members of scientific communities, rather than by individuals in isolation. Thus, features of communities can enhance or constrain the making of serendipitous discoveries. Specifically, I argue that communities that perceive the unexpected as potentially valuable, that support the epistemic agency of their members, and that encourage the sharing of knowledge, foster serendipitous discovery. I closely examine a recent case from clinical research with DBS—the case of the triggered memory—as a case of potential serendipity. The tripartite account of serendipity I articulate provides a lens through which I draw out several epistemological and ethical implications of pursuing serendipitous discovery within the context of clinical research, when human participants in research are the source of unexpected observations. In conclusion, I propose recommendations for pursuing serendipitous discovery in clinical research without compromising ethics.enserendipityscientific discoveryethics of clinical researchdeep brain stimulationThesis