Howie, ChelseaAhmad, TahaniMcFadden, KathrynCrooks, BruceMcNeely, P DanielWalling, SimonRutledge, RobertSahm, FelixHinz, FelixJabado, NadaKieran, MarkErker, Craig2023-01-192023-01-192022-10-25Howie C, Ahmad T, McFadden K, Crooks B, McNeely PD, Walling S, Rutledge R, Sahm F, Hinz F, Jabado N, Kieran M, Erker C. Diagnostics and prospective outcome of a diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters after surgical resection (DGONC): a case report. Neurooncol Adv. 2022 Oct 25;4(1):vdac170. doi: 10.1093/noajnl/vdac170. PMID: 36479060; PMCID: PMC9719366.http://hdl.handle.net/10222/82224Diffuse glioneuronal tumors with oligodendroglioma-like features and nuclear clusters (DGONC) are rare tumors of the central nervous system, having been added as a provi-sional diagnosis in the 2021 World Health Organization (WHO) Classification of Tumors of the central nervous system (CNS).1Retrospective studies report that these are most often mis-diagnosed and treated as high-grade tumors of the CNS.2,3However, this entity has demonstrated superior long-term survival in comparison. Given its novelty, there is currently no standard of care. We describe the diagnostic challenges, mo-lecular characteristics, prospective management, and outcome of a pediatric patient with a DGONC, with the aim to increase awareness of this entity and describe clinical behavior and di-agnostic uncertainties.https://creativecommons.org/licenses/by/4.0/TextLicensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).