Show simple item record

dc.contributor.authorLincoln, John
dc.date.accessioned2018-08-24T18:18:37Z
dc.date.available2018-08-24T18:18:37Z
dc.identifier.urihttp://hdl.handle.net/10222/74140
dc.description.abstractThis study evaluated contrast enhancement provided by Gadoxetate Disodium, a liver specific contrast agent. Image quality from cone-beam computed tomography was benchmarked against helical fan-beam computed tomography for comparison in cylindrical and ellipsoidal geometries. Concentrations were diluted to 0.0125 – 0.1 mmol/kg corresponding to expected physiological concentrations in the liver. CBCT imaging parameters tube voltage, tube current, and filtration were investigated on board a TrueBeam STx linear accelerator. All parameters were optimized according to the contrast-noise ratio, following the Rose criterion. Acceptable combinations of contrast dose, tube voltage, tube exposure-time product, and filtration gave CNR greater than three. This was found in a range of expected concentrations from 0.025 to 0.1 mmol/kg for a tube voltage of 100 kV, half-fan bowtie filtration, and exposures between 2025 and 5085 mAs. This research provides optimized pre-clinical dosing information and imaging parameters to use Gadoxetate Disodium in a clinical trial with CBCT.en_US
dc.language.isoenen_US
dc.subjectLiver Canceren_US
dc.subjectRadiotherapyen_US
dc.subjectImage guidanceen_US
dc.subjectContrast agentsen_US
dc.titleEvaluation of Cone Beam Computed Tomography Enhancement Using a Liver Specific Contrast Agent For Stereotactic Body Radiation Therapy Guidanceen_US
dc.date.defence2018-08-17
dc.contributor.departmentDepartment of Physics & Atmospheric Scienceen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinern/aen_US
dc.contributor.graduate-coordinatorDr. Theodore Moncheskyen_US
dc.contributor.thesis-readerDr. Sharon Clarkeen_US
dc.contributor.thesis-readerDr. Slawa Cwajnaen_US
dc.contributor.thesis-readerDr. Alasdair Symeen_US
dc.contributor.thesis-readerDr. Chris Thomasen_US
dc.contributor.thesis-supervisorDr. James Robaren_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.manuscriptsNoen_US
dc.contributor.copyright-releaseNoen_US
 Find Full text

Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record