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dc.contributor.authorKolathuru, Shyam Sundar
dc.date.accessioned2015-08-13T14:19:28Z
dc.date.available2015-08-13T14:19:28Z
dc.identifier.urihttp://hdl.handle.net/10222/59909
dc.description.abstractDipyridamole (DYP) is an adenosine uptake inhibitor used clinically as a coronary vasodilator, although the mechanism of action is not fully understood. The objective of my thesis research was to study the effect of DYP on ATP metabolism in the red blood cell (RBC) in response to acute cardiovascular injury induced by isoproterenol (30 mg/kg). Rats were each received either 10 mg/kg of DYP or normal saline twice daily for 5 doses by subcutaneous (sc) injection. Blood samples were collected from 0 to 6 hours for measurement of circulating ATP and adenosine concentrations. Isoproterenol induced 50% mortality and increased the breakdown of ATP in the RBC to AMP and adenosine in the control group. Treatment with DYP decreased mortality to 25%, and significantly reduced the breakdown of ATP in the RBC. In conclusion, DYP is protective against cardiovascular injury induced by isoproterenol most likely by preserving ATP in the RBC.en_US
dc.language.isoen_USen_US
dc.subjectAdenosine Uptake Inhibitoren_US
dc.subjectATP Metabolismen_US
dc.subjectRed Blood Cellsen_US
dc.subjectCardiovascular Injuryen_US
dc.subjectMyocardial Ischemiaen_US
dc.subjectBiomarkeren_US
dc.titleEffect Of Dipyridamole On ATP Metabolism In The Red Blood Cells And Cardiovascular Protectionen_US
dc.typeThesisen_US
dc.date.defence2015-07-09
dc.contributor.departmentCollege of Pharmacyen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinerDr. Christian Lehmannen_US
dc.contributor.graduate-coordinatorDr. David Jakemanen_US
dc.contributor.thesis-readerDr. Remi Aguen_US
dc.contributor.thesis-readerDr. Zhaolin Xuen_US
dc.contributor.thesis-supervisorDr.Pollen Yeungen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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