Browsing Faculty of Graduate Studies Online Theses by Subject "Obesity"
Now showing items 1-17 of 17
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ASSESSMENT OF RESPIRATORY SYSTEM MECHANICS IN ADULTS: EFFECT OF WEIGHT LOSS, POSTURE, BRONCHODILATION AND ARTEFACTS ON RESPIRATORY IMPEDANCE AND ITS REPEATABILITY
(2016-09-29)Obesity is associated with respiratory symptoms that often improve with weight loss. However, traditional methods of testing pulmonary function such as spirometry and plethysmography show little or no changes with weight ... -
AUTOTAXIN IS NUTRITIONALLY REGULATED AND ALTERS MITOCHONDRIAL FUNCTION IN OBESITY-INDUCED INSULIN RESISTANCE
(2019-08-28)The skeletal muscle is a major site of insulin stimulated glucose disposal. Skeletal muscle insulin sensitivity can be influenced by multiple circulating nutritional, hormonal, neuronal and bioactive factors, including ... -
CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS
(2011-11-08)Obesity, characterized by an excess of adipose tissue, is an established risk factor for cardiovascular disease and type II diabetes. Different mechanisms linking obesity with these comorbidities have been postulated but ... -
DEVELOPMENT OF A CHEMOKINE-LIKE RECEPTOR 1 BIOASSAY TO STUDY THE IMPACT OF OBESITY ON ACTIVE CHEMERIN PRODUCTION IN OBESE HUMANS
(2014-12-17)Prochemerin is an adipose-secreted molecule that is cleaved by extracellular proteases of the inflammatory, coagulation, and fibrinolytic cascades to active chemerin. Plasma and serum total chemerin (prochemerin + active ... -
Economic Determinants of Obesity in Canadian Adults
(2012-08-30)This paper examines how socioeconomic status and economic insecurity relate to obesity in working-age Canadians between 2000 and 2010. First, I attempt to explain the gender specific gradients in body mass. Second, I test ... -
THE EFFECT OF DIETARY PROTEIN ON SATIETY AND WEIGHT LOSS DURING INTERMITTENT FASTING IN OVERWEIGHT AND OBESE WOMEN
(2023-10-10)Energy restriction, including IER regimens, is one of the most important obesity treatment and weight-control strategies. These regimens provide health benefits associated with weight reduction. With energy restriction ... -
EXPLORING THE RELATIONSHIP BETWEEN ECONOMIC INSECURITY AND HEALTH OUTCOMES
(2015-04-06)This dissertation examines the relationship between economic insecurity and health outcomes for Canadians age 25 to 64 using the National Population Health Survey (NPHS) - a longitudinal dataset. Chapter 2 examines the ... -
Intergenerational Effects of Maternal Health on Pregnancy and Neonatal Outcomes in Nova Scotian Children
(2022-08-31)Maternal pre-pregnancy body mass index (BMI) is associated with first-generation health outcomes. The literature suggests an increased risk of low birthweight in infants born to mothers who are underweight, while infants ... -
NUTRIENT REGULATION OF AUTOPHAGY IN THE HEART
(2016-09-02)Impaired cardiac metabolism in the obese-diabetic heart leads to glucolipotoxicity and ensuing cardiomyopathy. Glucolipotoxicity causes cardiomyocyte injury by increasing energy insufficiency and by dysregulating proteolysis. ... -
OBESITY AND ITS INFLUENCE ON KNEE JOINT CONTACT FORCES IN INDIVIDUALS WITH MODERATE KNEE OSTEOARTHRITIS
(2014-08-22)Obesity is known as a major risk factor for the development and progression of knee OA. It has been proposed to affect the joint through linked mechanical and metabolic factors. However, its precise role in the pathomechanics ... -
Predicting Frontal Lobe H-MRS Metabolite Levels Using Obesity and Metabolic Markers in Individuals with Bipolar Disorder: A Meta-Analysis and Cross-Sectional Study
(2022-07-29)Obesity and related metabolic disorders, such as metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) impact the brain, particularly in the frontal lobe. Individuals with severe and persistent mental illness (SPMI), ... -
THE ROLE OF LIPID PHOSPHATE PHOSPHATASE 3 IN CARDIAC ENERGY METABOLISM
(2023-07-31)Lysophosphatidic acid (LPA) is a bioactive lipid that is generated by autotaxin (ATX) in circulation and is implicated in obesity induced cardiomyopathy. LPA signaling is terminated by lipid phosphate phosphatase 3 (LPP3) ... -
THE ROLE OF LYSOPHOSPHATIDIC ACID AND AUTOTAXIN IN OBESITY-INDUCED CARDIAC INSULIN RESISTANCE
(2017-08-09)The metabolic changes to adipose tissue during obesity can induce cardiac insulin resistance. During obesity and diabetes, cardiac metabolic flexibility is reduced, which may lead to impaired ATP production, elevated ... -
The role of secretion associate ras-related GTPase 1b in skeletal muscle insulin signaling
(2023-04-24)Dysfunctional branched-chain amino acid (BCAA) catabolism increases intracellular branched-chain keto acids (BCKA), which inhibit insulin signaling. The discovery of Secretion Associated Ras-related GTPase-1B (Sar1b), a ... -
Role of Transcription Factor EB in obesity mediated cardiac dysfunction
(2023-08-21)Lipotoxic complications drive impairment in cardiac function during obesity. Specifically, palmitate toxicity induces ER stress, calcium mishandling and perturbations in lysosomal function by downregulating transcription ... -
Tumor necrosis factor-{alpha} amplifies adipose-derived chemerin production and bioactivation
(2013-03-20)Due to its escalating prevalence, obesity is becoming a leading cause of morbidity and mortality worldwide. Obesity is a complex health problem accompanied by metabolic abnormalities and low-grade inflammation that increases ... -
Validation of a Commercial Three-Dimensional Whole-Body Laser Scanner for the Collection of Obesity-Related Measurements
(2014-09-03)This study aimed to develop a systematic method of comparing manual and digital anthropometric measurements and validate a commercial three-dimensional laser scanner, for measurements related to obesity. Firstly, novel ...