Browsing by Subject "Amyotrophic Lateral Sclerosis"
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Cellular Mechanisms Regulating Neuromuscular Junction Stability and Plasticity in Normal and Diseased Mice
(2021-01-07)The stability of the neuromuscular junction (NMJ) is critical for maintaining independence and quality of life. Therefore, understanding the mechanisms that underlie this stability is of paramount importance to be able to ... -
Development of a novel in vitro model system to characterize the role of activity in motor neurons during development and disease
(2017-05-11)Neural activity modulates motor axon guidance and synaptic function during development. Differences in neural activity also contribute to the demise of specific motor neuron subtypes in amyotrophic lateral sclerosis (ALS). ... -
A Sex-dependent Response to dl-PHPB in an Amyotrophic Lateral Sclerosis Disease Mouse Model
(2021-04-28)Amyotrophic Lateral Sclerosis is a fatal neurodegenerative disease affecting upper and lower motor neurons resulting in their death. There are currently only two FDA approved drugs for its treatment, and both offer mild ...