Browsing by Title
Now showing items 19245-19264 of 38074
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Investigating the Molecular Mechanisms of CBP/p300 Recruitment by the Transcriptional Regulators MITF and β-catenin
(2023-08-11)CREB-binding protein (CBP) and its homolog p300 (CBP/p300) are sequestered by transcription factors to thousands of promoters and enhancers throughout the human genome, where they modify chromatin structure and enhance ... -
INVESTIGATING THE RELATIONSHIP BETWEEN HOUSEHOLD FOOD INSECURITY AND ACADEMIC PERFORMANCE AMONG NOVA SCOTIA ELEMENTARY SCHOOL STUDENTS
(2019-04-29)Background: Education is a fundamental determinant of health, and as such, good academic performance of children has instrumental importance for their health. Household food insecurity, given its association with poor ... -
Investigating the relationship between mammographic breast density and triple negative breast cancer in Nova Scotia, Canada
(2020-04-13)The study objectives were to estimate the association between mammographic breast density (MBD) and triple negative breast cancers (TNBC); as well as to estimate the discriminatory ability of MBD, alone and with clinical ... -
INVESTIGATING THE REMAINING FATIGUE RELIABILITY OF AN AGING ORTHOTROPIC STEEL PLATE DECK
(2014-12-10)The A. Murray MacKay Bridge is an aging structure which opened to traffic over 40 years ago. With many of our structures aging, the ability to make confident management decisions supported by reliable engineering has become ... -
INVESTIGATING THE ROLE OF ACTIVATION-INDUCED CYTIDINE DEAMINASE IN CHLAMYDIA PATHOGENESIS
(2023-06-14)Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections around the world. The role of antibodies in Chlamydia pathogenesis remains inconclusive. Activation-induced cytidine deaminase (AID) ... -
Investigating the role of call similarity in a tree swallow (Tachycineta bicolor) parent-offspring recognitionmechanism
(2011-03)Parent-offspring recognition is a mechanism that allows parents and offspring to recognize each other by specific cues. The mechanism is predicted to be well developed in species that are at a high risk for misdirecting ... -
Investigating the role of frailty in the expression of dementia
(2020-08-28)Background: Frailty is related to neuropathological features of Alzheimer’s disease (AD) as well as cognitive decline and dementia. Objectives: 1) determine whether frailty moderates the relationship between neuropathology ... -
INVESTIGATING THE ROLE OF MLLT11 IN CORTICAL DEVELOPMENT
(2023-08-18)The formation of connections within the mammalian neocortex is highly regulated by both extracellular guidance mechanisms and intrinsic gene expression programs. Dysregulation of these programs has been shown to cause a ... -
INVESTIGATING THE ROLE OF MLLT11 IN SUBVENTRICULAR ZONE NEUROGENESIS AND DEVELOPMENT OF THE OLFACTORY BULB
(2022-08-24)Neurogenesis is the process of generating new neurons in developing and adult brains. This process imparts plasticity to the mammalian brain by allowing novel connections to form and replacing damaged neurons. In later ... -
Investigating the role of MLLT11 in the development of cortical hem derivatives and hippocampal neurogenesis
(2021-03-31)The mammalian Cortical Hem plays a key role in orchestrating the formation of Cajal-Retzius cells, the Choroid Plexus, and hippocampus, a structure crucial to cognition and spatial learning. While several key regulators ... -
Investigating the role of mutanthuntingtin in altered transcription in Huntington's disease.
(Dalhousie University, 2007) -
INVESTIGATING THE ROLE OF NICOTINIC ACID PHOSPHORIBOSYL TRANSFERASE IN CANCER
(2019-11-28)Currently, there is interest in targeting cancer stem cells (CSCs) for cancer therapy. CSCs are characterized by self-renewal and the potential to differentiate into various tumor cell types. One therapeutic strategy is ... -
Investigating the role of the anaerobic protist Blastocystis in the gut microbiome by metagenomic analysis
(2021-05-05)Blastocystis are amongst the most prevalent microbial eukaryotes inhabiting the gastrointestinal tracts of mammals. A bioinformatic workflow was developed to detect Blastocystis in gut metagenomic data and applied to 996 ... -
Investigating the Roles of Mast Cells and Innate Activators in Oral Tolerance
(2013-09-09)Oral tolerance is the state of immunologic non-responsiveness that is established following oral antigen consumption. Failures of oral tolerance can result in food allergy. The mechanisms regulating oral tolerance are ... -
Investigating the Secretion of HtpB, the Multifunctional Chaperonin of Legionella pneumophila
(2016-08-31)Legionella pneumophila is a ubiquitous freshwater pathogen of unicellular eukaryotes, namely several species of amoeba. Following inhalation of Legionella-contaminated aerosols, susceptible human populations may also develop ... -
INVESTIGATING THE STRENGTH AND FAILURE MECHANISM OF HIGHLY INTERLOCKED JOINTED PILLARS USING 2D CONTINUUM MODELS
(2021-03-29)Pillars are commonly used in underground mines to maintain the stability and integrity of the openings. An optimum design of mine pillars dictates that the pillars should be as small as possible and meet the load-bearing ... -
INVESTIGATING THE TUMOUR SUPPRESSING ROLE OF HACE1 AND ITS NOVEL CONTRIBUTION TO CARDIAC DEVELOPMENT USING THE ZEBRAFISH MODEL
(2017-10-12)HACE1 is an E3 ubiquitin-ligase that is epigenetically downregulated in various malignancies. The mechanisms underlying its role in tumourigenesis and in normal vertebrate development have not been well elucidated. We ... -
INVESTIGATING THE UNDERLYING IMMUNLOGICAL MECHANISMS OF PREVIOUSLY INFECTED SARS-CoV-2 INDIVIDUALS IN A UNIVERSITY SETTING: A CROSS-SECTIONAL, SEROPREVALENCE STUDY
(2023-12-13)Since December 2019, the COVID-19 pandemic has resulted in more than 770 million cases of the disease and over 6.9 million deaths worldwide. Although over 70% of the global population has been vaccinated against the ... -
Investigating the Use of Cellular Precision Biopatterning for Generating Functional Skin Equivalents
(2018-04-30)The production of skin equivalents for treating full-thickness wounds has been a long-standing challenge in the field of skin tissue engineering. Although several techniques (e.g., skin substitutes and cell-based therapies) ... -
Investigating Tom1 as a Candidate Regulator of Ptch1
(2012-12-14)Sonic hedgehog (Shh) is a signaling molecule that is involved in patterning the embryo and regulates adult stem cell homeostasis. Patched1 (Ptch1) is the receptor for Shh and upon binding to Shh is endocytosed, allowing ...
