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Recent Submissions

Access status: Open Access ,
Investigations Into the Synthesis, Physicochemical Characterization and Enzymology of Substituted Benzoxaboroles, Phosphonic-boronic acid anhydrides and Exoglycals
(2026-01-30) Ospanow, Elisa; Yes; Doctor of Philosophy; Department of Chemistry; Not Applicable; Dr. Christopher Cairo; Yes; Dr. Stephen Bearne; Dr. Carlie Charron; Dr. Alex Speed; Dr. David L. Jakeman
This thesis describes the design, synthesis, and evaluation of novel chemical scaffolds for the development of potent enzyme inhibitors. The work explores the strategic incorporation of boron and phosphorus to investigate their effect on the physicochemical properties and biological activity. Three distinct compound classes were investigated: benzoxaborole-phosphorus(III) hybrids, phosphonic acid-boronic acid anhydrides, and exoglycal derivatives. A one-pot synthetic route was developed to access previously unreported benzoxaborole-phosphorus(III) hybrids. These compounds demonstrated enhanced aqueous stability and oxidative resistance compared to conventional boronic acids. Subsequently, phosphonic acid-boronic acid anhydrides were introduced as a novel scaffold, where the appended phosphorus group was shown to affect the boron atom's acidity and stability. Biological evaluation demonstrated these boron-phosphorus compounds to be promising inhibitors of Class A, C, and D β-lactamases. A series of exoglycals were synthesized as transition-state analogues for glycoside hydrolase family 3 (GH3). One compound exhibited potent competitive inhibition against the model enzyme EryBI, with affinity comparable to the natural substrate, by mimicking the half-chair conformation of the hydrolysis transition state.
Access status: Open Access ,
Health Policy Capacity Framework Adaptation using the Delphi method
(Dalhousie University Faculty of Health, 2018) Logan Lawrence; Adrian Mackenzie; Patrick McGrath; Janet Curran
Ensuring the success of health policies requires substantial policy capacity. An existing conceptual framework for policy capacity was adapted based on input from health policy experts using the Delphi method. The resulting framework is a tool to facilitate the assessment of health policy capacity.
Access status: Open Access ,
Physical Literacy in the Early Years: A Loose Parts Intervention
(Dalhousie University Faculty of Health, 2018) Natalie E. Houser; Michelle Stone; Angela M Kolen; Daniel Rainham; Joan Turner; Sara Kirk; Laurene Rehman; Jane Cawley
The Physical Literacy in the Early Years project is examining whether preschoolers who participate in active outdoor play, facilitated by educators trained in embedding loose parts into outdoor spaces, enhances their physical literacy. The study‘s protocol will be shared, along with the potential impact on policy/practice changes in early years.
Access status: Open Access ,
Translating Collaboration into Practice: Using Simulation to Enhance Team Functioning
(Dalhousie University Faculty of Health, 2018) Tanya Louise Dutton; Karen Bassett; John Kyle
Collaborative practice within health care teams has been shown to be positive for the patient, provider and system. Interprofessional collaborative practice can be challenging, with barriers at every turn. Simulation can help identify and help participants enact and see the change that is possible.
Access status: Open Access ,
Let‘s put our lessons to use: Refining a framework for building on successful patient and public engagement in health research
(Dalhousie University Faculty of Health, 2018) Brian Condran; Grace Warner; Larry Baxter; Tara Sampalli; Ruth Martin-Misener; Elizabeth Michael
This workshop will involve participants in refining a draft framework for scaling-up successful elements of partnerships between researchers, patients, the public, and other stakeholders in health research. In this context, ‘scaling-up‘ involves identifying ‘what works‘ to make partnerships successful and ways to build on these successes in other projects.
Access status: Open Access ,
Measuring Adverse Childhood Experiences and Resilience in Primary Health Care
(Dalhousie University Faculty of Health, 2018) Nancy Marie Ross; Sara Torres; Robert Gilbert
This presentation will summarize results from a research project piloted among three hundred adult patients of the Lunenburg Family Health Clinic who completed a survey that measured adverse childhood experiences, current health challenges and factors promoting resilience. Future implications for multi-disciplinary and collaborative care settings will be discussed.