Browsing by Subject "TFEB"

Now showing items 1-3 of 3

  • NUTRIENT REGULATION OF AUTOPHAGY IN THE HEART 

    Trivedi, Purvi (2016-09-02)
    Impaired cardiac metabolism in the obese-diabetic heart leads to glucolipotoxicity and ensuing cardiomyopathy. Glucolipotoxicity causes cardiomyocyte injury by increasing energy insufficiency and by dysregulating proteolysis. ...

  • ROLE OF TRANSCRIPTION FACTOR EB (TFEB) IN CARDIAC HEALTH AND DISEASE 

    Trivedi, Purvi (2020-12-18)
    Cardiomyopathy is prevalent and the leading cause of mortality among obese and diabetic patients. Abnormalities in cardiac energy metabolism trigger myocyte dysfunction that precedes the onset of cardiomyopathy. Lack of ...

  • Role of Transcription Factor EB in obesity mediated cardiac dysfunction 

    Pisapati, Adithi (2023-08-21)
    Lipotoxic complications drive impairment in cardiac function during obesity. Specifically, palmitate toxicity induces ER stress, calcium mishandling and perturbations in lysosomal function by downregulating transcription ...