Browsing by Subject "Medicinal chemistry"
Now showing items 1-2 of 2
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The discovery of a novel series of amyloid-β antiaggregants based on the structure of 3-hydroxyanthranilic acid: a detailed analysis of the mechanism of action underpinning antiaggregant activity
(2015-05-01)Alzheimer’s disease (AD) is the fourth leading cause of death in the industrialized nations, yet there are no disease-stabilizing therapies currently in use. The amyloid hypothesis suggests that oligomeric species of the ... -
Studies on Ligand Binding and Catalysis by Isoleucine Epimerase and CTP Synthase
(2023-06-13)Isoleucine 2-epimerase participates in production of branched-chain D-amino acids. We showed that L- and D-neopentyl glycine are substrates of LbIleE, with Km values of 0.65 ± 0.03 mM and 0.43 ± 0.03 mM, respectively. The ...