dc.contributor.author | El-Rabahi, Tony | |
dc.date.accessioned | 2023-07-26T18:04:32Z | |
dc.date.available | 2023-07-26T18:04:32Z | |
dc.date.issued | 2023-07-25 | |
dc.identifier.uri | http://hdl.handle.net/10222/82728 | |
dc.description.abstract | Background: Pulmonary arterial hypertension (PAH) is a progressive incurable disease with unclear etiology. Primary cause of death in PAH patients is right (-sided) heart failure, occurring as a direct consequence of increased right ventricular (RV) afterload. Importantly, around 25% of these deaths have been linked to cardiac arrhythmias. However, mechanisms underlying arrhythmia susceptibility in patients with elevated pulmonary arterial and RV pressure remains unclear
Conclusions: PAH in Fischer rats treated with MCT was associated with electrical remodeling and reduced vascular density. These changes in RV may contribute to increased susceptibility to arrhythmias and sudden death in PAH. | en_US |
dc.language.iso | en | en_US |
dc.subject | Cardiac Arrhythmias | en_US |
dc.subject | Pulmonary Hypertension | en_US |
dc.subject | Pulmonary Arterial Hypertension | en_US |
dc.subject | Electrical Remodeling | en_US |
dc.title | EXPLORING THE SUSCEPTIBILITY TO CARDIAC ARRHYTHMIAS AND UNDERLYING MECHANISMS IN PULMONARY ARTERIAL HYPERTENSION | en_US |
dc.type | Thesis | en_US |
dc.date.defence | 2023-06-14 | |
dc.contributor.department | Department of Physiology & Biophysics | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | n/a | en_US |
dc.contributor.graduate-coordinator | Dr. Y. El-Hiani | en_US |
dc.contributor.thesis-reader | Dr. T. Alexander Quinn | en_US |
dc.contributor.thesis-reader | Dr. P. Kienesberger | en_US |
dc.contributor.thesis-reader | Dr. J Sapp | en_US |
dc.contributor.thesis-supervisor | Dr. K.R Chaudhary | en_US |
dc.contributor.ethics-approval | Received | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |