| dc.contributor.author | Hren, Rok. | en_US |
| dc.date.accessioned | 2014-10-21T12:37:59Z | |
| dc.date.available | 1996 | |
| dc.date.issued | 1996 | en_US |
| dc.identifier.other | AAINN15935 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10222/55139 | |
| dc.description | Body surface potential maps recorded during catheter pace mapping can facilitate the localization of the site of origin of ventricular tachycardia. This study investigated the value of a realistic computer model of the human ventricular myocardium in identifying sites of ectopic activation using simulated body surface potential maps as templates. Our model of the human ventricular myocardium features an anatomically accurate geometry and an intramural anisotropic structure that were reconstructed with a spatial resolution of 0.5 mm. It simulates the electrotonic interactions of cardiac cells by solving a nonlinear parabolic partial differential equation, but it behaves as a cellular automaton when the transmembrane potential exceeds the threshold value. | en_US |
| dc.description | We successfully validated our model by comparing the simulated activation sequences of isochronal maps, epicardial potential maps, and body surface potential maps with the measured sequences of maps reported in the literature. Based on our simulations, we have developed clinical protocols for differentiating among septal accessory pathways in Wolff-Parkinson-White syndrome and for localizing the origin of idiopathic ventricular tachycardia. By systematically pacing the left ventricular and right ventricular endocardial surfaces in our ventricular model, we generated a data base of isointegral maps, which provides a high-resolution reference frame for localizing distinct endocardial pacing sites. This data base promises to be a useful tool in improving the performance of catheter pace mapping used in combination with body surface potential mapping. Overall, the results demonstrate that our computer model of the human ventricular myocardium is well suited for complementing a data base of isointegral maps obtained during clinical pace mapping and can help enhance the efficacy of the ablative treatment of ventricular arrhythmias. | en_US |
| dc.description | Thesis (Ph.D.)--Dalhousie University (Canada), 1996. | en_US |
| dc.language | eng | en_US |
| dc.publisher | Dalhousie University | en_US |
| dc.publisher | | en_US |
| dc.subject | Biology, Animal Physiology. | en_US |
| dc.subject | Biophysics, Medical. | en_US |
| dc.title | A realistic model of the human ventricular myocardium: Application to the study of ectopic activation. | en_US |
| dc.type | text | en_US |
| dc.contributor.degree | Ph.D. | en_US |
