| dc.contributor.author | Espey, Mary Jane. | en_US |
| dc.date.accessioned | 2014-10-21T12:35:47Z | |
| dc.date.available | 1995 | |
| dc.date.issued | 1995 | en_US |
| dc.identifier.other | AAINN05194 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10222/55031 | |
| dc.description | Monoamines, such as noradrenaline (NA) and serotonin (5HT), are contained in descending pathways to the spinal cord. These compounds modulate several functions, such as antinociception and locomotion, at a spinal level. There is evidence to suggest that NA is the spinal transmitter in pathways forming the descending limb of the spino-bulbo-spinal reflex underlying micturition. 5HT has been implicated as an inhibitory modulator of micturition. We proposed to examine the physiological role of NA and 5HT in the spinal control of micturition. A conscious preparation for monitoring voiding was developed. Monoaminergic transmission was modulated on an acute and chronic basis, using intrathecal administration of selective receptor ligands and neurotoxins, respectively. | en_US |
| dc.description | Blockade of noradrenergic transmission did not alter bladder function, suggesting that NA is not the spinal mediator of micturition. Acute blockade of scrotonergic transmission decreased bladder capacity while stimulation of serotonergic receptors increased capacity, suggesting that 5HT, at a spinal level, can inhibit micturition. A modulatory action of serotonergic receptors on the ascending limb of micturition was investigated in an acute, anesthetized preparation. 5HT1D/2A/2C and 5HT3 receptors were implicated in the inhibition of ascending activity, which was consistent with the effects of serotonergic ligands in the conscious preparation. | en_US |
| dc.description | The possibility that 5HT, as a spinal inhibitory modulator of bladder function, could diminish detrusor hyperreflexia after spinal cord injury was examined in a chronic, spinally-transected preparation. However, cats initially prepared for these experiments did not develop reflex bladder activity. Further experiments suggested that cutaneous afferent input from the perineum can influence the emergence of reflex bladder activity. 5HT was tested in cats with reflex bladder activity after spinal transection and produced opposite effects to those seen in spinally-intact cats. However, 2-methyl-5HT, a 5HT3 agonist, increased the volume at which micturition occurred. These results suggest that some, but not all, aspects of serotonergic pharmacology are altered in the portion of the spinal cord isolated by transection. | en_US |
| dc.description | Thesis (Ph.D.)--Dalhousie University (Canada), 1995. | en_US |
| dc.language | eng | en_US |
| dc.publisher | Dalhousie University | en_US |
| dc.publisher | | en_US |
| dc.subject | Health Sciences, Pharmacology. | en_US |
| dc.title | Role of descending monoamines in the spinal control of micturition in cat. | en_US |
| dc.type | text | en_US |
| dc.contributor.degree | Ph.D. | en_US |
