dc.contributor.author | Li, Zhiyu | |
dc.date.accessioned | 2014-08-26T12:37:17Z | |
dc.date.available | 2014-08-26T12:37:17Z | |
dc.date.issued | 2014-08-26 | |
dc.identifier.uri | http://hdl.handle.net/10222/54045 | |
dc.description.abstract | Bioactive low molecular weight protein hydrolysates need to be protected, transported to the targeted absorption site, and released in a controlled manner to optimize their effectiveness during oral administration. The focus of this research was to develop a chitosan-coated liposomal oral delivery system with milk fat globule membrane (MFGM) phospholipids for antidiabetic Atlantic salmon protein hydrolysates (SPH). The size, zeta potential, entrapment efficiency, stability during freeze-drying and freeze thawing, and long-term storage abilities were investigated as a function of phospholipid concentration and chitosan coating concentration. Chitosan coating greatly improved the stability of MFGM liposomes. The maximum encapsulation efficiency (71.3%) and physical stability were achieved with 10% MFGM and 0.4% chitosan. Chitosan coating significantly prolongs the release of SPH in simulated biological fluids. In conclusion, liposomes with “optimal” chitosan-coating-concentration show great promise as a potential new delivery system for protein hydrolysates. However, the bioactivity of encapsulated SPH need to be tested. | en_US |
dc.language.iso | en | en_US |
dc.subject | Encapsulation | en_US |
dc.subject | Liposome | en_US |
dc.subject | Chitosan | en_US |
dc.subject | Protein hydrolysates | en_US |
dc.title | ENCAPSULATION OF BIOACTIVE SALMON PROTEIN HYDROLYSATES WITH CHITOSAN-COATED LIPOSOMES | en_US |
dc.date.defence | 2014-08-14 | |
dc.contributor.department | Department of Process Engineering and Applied Science | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | n/a | en_US |
dc.contributor.graduate-coordinator | Gibson, M | en_US |
dc.contributor.thesis-reader | Su-Ling Brooks | en_US |
dc.contributor.thesis-reader | Amyl Ghanem | en_US |
dc.contributor.thesis-supervisor | Tom Gill, Allan Paulson | en_US |
dc.contributor.ethics-approval | Not Applicable | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |