Recent Submissions

  • Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans 

    Syvitski, R. T., X. L. Tian, K. Sampara, A. Salman, et al. 2007. "Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans." Journal of Bacteriology 189(4): 1441-1450.
    Streptococcus mutans secretes and utilizes a 21-amino-acid signaling peptide pheromone to initiate quorum sensing for genetic competence, biofilm formation, stress responses, and bacteriocin production. In this study, we ...
  • Detachment of Streptococcus mutans biofilm cells by an endogenous enzymatic activity 

    Lee, SF, YH Li, and GH Bowden. 1996. "Detachment of Streptococcus mutans biofilm cells by an endogenous enzymatic activity." Infection and immunity 64(3): 1035-1038.
    Previous studies have shown that Streptococcus mutans NG8 possesses an endogenous surface protein-releasing enzyme (SPRE) activity that liberates its own surface proteins (S. P. Lee, Infect. Immun. 60:4032-4039, 1992). The ...
  • Quorum sensing and bacterial social interactions in biofilms 

    Li, Y. H., and X. Tian. 2012. "Quorum sensing and bacterial social interactions in biofilms." Sensors (Basel, Switzerland) 12(3): 2519-2538.
    Many bacteria are known to regulate their cooperative activities and physiological processes through a mechanism called quorum sensing (QS), in which bacterial cells communicate with each other by releasing, sensing and ...
  • The BceABRS four-component system regulates the bacitracin-induced cell envelope stress response in Streptococcus mutans 

    Ouyang, J., X. L. Tian, J. Versey, A. Wishart, et al. 2010. "The BceABRS four-component system regulates the bacitracin-induced cell envelope stress response in Streptococcus mutans." Antimicrobial Agents and Chemotherapy 54(9): 3895-3906.
    Streptococcus mutans is known to be resistant to bacitracin, a cyclic polypeptide antibiotic produced by certain species of the genus Bacillus. This property is often exploited in the isolation of S. mutans strains from ...
  • A novel target-specific, salt-resistant antimicrobial peptide against the cariogenic pathogen Streptococcus mutans 

    Mai, J., X. L. Tian, J. W. Gallant, N. Merkley, et al. 2011. "A novel target-specific, salt-resistant antimicrobial peptide against the cariogenic pathogen Streptococcus mutans." Antimicrobial Agents and Chemotherapy 55(11): 5205-5213.
    In this study, we constructed and evaluated a target-specific, salt-resistant antimicrobial peptide (AMP) that selectively targeted Streptococcus mutans, a leading cariogenic pathogen. The rationale for creating such a ...