David Jakeman

Professor

Graduate Coordinator

Cross-appointed to Chemistry

Email: david.jakeman@dal.ca

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Recent Submissions

  • A Method for Structure-Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable Streptococci 

    Tian, XiaoLin, Raymond T. Syvitski, TianLei Liu, Nadine Livingstone, et al. 2009. "A Method for Structure-Activity Analysis of Quorum-Sensing Signaling Peptides from Naturally Transformable Streptococci." Biological Procedures Online 11(1): 207-226.
    Many species of streptococci secrete and use a competence-stimulating peptide (CSP) to initiate quorum sensing for induction of genetic competence, bacteriocin production, and other activities. These signaling molecules ...
  • Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans 

    Syvitski, Raymond T., Xiao-Lin Tian, Kamal Sampara, Alan Salman, et al. 2007. "Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans." Journal of Bacteriology 189(4): 1441-1450.
    Streptococcus mutans secretes and utilizes a 21-amino-acid signaling peptide pheromone to initiate quorum sensing for genetic competence, biofilm formation, stress responses, and bacteriocin production. In this study, we ...
  • Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates 

    Huestis, Malcolm P., Gaia A. Aish, Joseph P. M. Hui, Evelyn C. Soo, et al. 2008. "Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates." Organic & Biomolecular Chemistry 6(3): 477-484.
    Structure-based design of alkyl sugar-1-phosphates provides an efficient nucleotidylyltransferase-catalyzed synthesis of a series of new lipophilic sugar nucleotides possessing long or branched alkyl chains, thereby ...
  • Antimicrobial Activities of Jadomycin B and Structurally Related Analogues 

    Jakeman, David L., Srinivasulu Bandi, Cathy L. Graham, Taryn R. Reid, et al. 2009. "Antimicrobial Activities of Jadomycin B and Structurally Related Analogues." Antimicrobial Agents and Chemotherapy 53(3): 1245-1247.
    Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ...