Browsing by Subject "frailty"
Now showing items 1-7 of 7
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The association between sedentary behaviour, moderate-vigorous physical activity and frailty
(2014-08-25)This thesis examined the association between sedentary behaviour, moderate-vigorous intensity activity (MVPA) and frailty using cross-sectional data in 50+year olds from the 2003-2006 National Health and Nutrition Examination ... -
Construction and Validation of a Frailty Index for the Inflammatory Bowel Disease Population
(2024-08-21)Frailty can be defined as a state of vulnerability to adverse health events. In this project, a standardized method for constructing a frailty index was followed using data from the SPOR IMAGINE IBD cohort. We constructed ... -
IDENTIFYING FRAILTY IN CANCER SURVIVORS: PATTERNS OF CANCER FOLLOW-UP CARE AND IMPLICATIONS FOR PERSONALIZED SURVIVORSHIP MODELS
(2023-01-26)Improved cancer care has increased the number of survivors, straining Canada’s cancer care system. As survivors age, they may become frail, resulting in complex needs better addressed through alternative care models. No ... -
The Impact of Age and Frailty on the Fischer-344 Rat Heart
(2017-05-11)The purpose of this study was to develop a frailty index (FI) for rats, and characterize the impact of age and frailty on cardiac parameters at baseline and following cardioplegic arrest. Data on survival and 45 variables ... -
Influence of ACE inhibitors on frailty, cardiac contractile function and calcium homeostasis in middle-aged male and female mice
(2018-09-28)Angiotensin Converting Enzyme (ACE) inhibitors were chronically administered to middle-aged male and female mice to determine whether treatment with ACE inhibitors attenuates frailty and whether this is accompanied by ... -
Influence of Age and Frailty on Intestinal and Hepatic Bile Acid Transport in Male C57BL/6 Mice
(2017-09-15)Bile acids regulate their own synthesis as well as glucose and lipid metabolism. Bile acid homeostasis is maintained in part by enterohepatic circulation, which requires the concerted activity of multiple transporters, ... -
INSIGHTS INTO THE BASIS FOR ATRIAL ELECTROPHYSIOLOGICAL REMODELLING AND ARRHYTHMOGENESIS IN HYPERTENSIVE HEART DISEASE, AGEING, AND FRAILTY
(2019-11-28)Atrial fibrillation (AF) is a major complication in heart disease and is linked to alterations in Angiotensin II (Ang II) signalling; however, the effects of Ang II on atrial electrophysiology is poorly understood. Natriuretic ...