Browsing by Subject "Chlamydia"
Now showing items 1-6 of 6
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Investigating mast cell responses and the functional role of Toll-Like Receptor 2 in Chlamydia pathogenesis
(2023-08-31)Chlamydia trachomatis (Ct) is a Gram-negative obligate intracellular bacterium that can cause severe reproductive tract complications in females. In this thesis, I have investigated two aspects of the immune response in ... -
Repeated, low dose Chlamydia infections trigger aberrant immune responses and weakened host resistance against secondary challenge
(2022-05-03)Chlamydia trachomatis infections endanger women’s health, but translational gaps between animal models and human disease states persist. I compared immune responses in mice receiving repeated, low dose infections (5X) with ... -
THE ROLE OF IL-17RA- AND IL-17RC-DEPENDENT SIGNALS ON NON-HEMATOPOIETIC CELLS IN SHAPING THE HOST IMMUNE RESPONSES DURING CHLAMYDIA RESPIRATORY TRACT INFECTION
(2018-09-28)The role of IL-17-family cytokines and their receptor-mediated signaling in host defense is complex. During my graduate study, I investigated the specific role of non-hematopoietic IL-17 receptor A (IL-17RA) and IL-17RC ... -
The role of innate-like B1 cells in the regulation of sex-dependent immune responses to Chlamydia infection
(2019-11-28)Chlamydia infections predominantly impact women’s health and the biological basis underlying the sex-dependent disparity is unclear. I demonstrate that female mice are significantly more susceptible to respiratory Chlamydia ... -
The role of mast cells and toll-like receptor 2 (TLR2) in host defence and pathology following Chlamydia infection
(2019-01-15)Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection and the leading cause of infectious blindness worldwide. A comprehensive understanding of immune responses to Ct, and how they lead to ... -
The role of regulatory T and B cells in host responses to Chlamydia genital tract infection
(2016-01-14)The existence of regulatory T and B cells as important cellular entities in immune responses to infection has been established. The focus of this study was to dissect the role of regulatory T and B cells in regulating the ...