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dc.contributor.authorHickey, Megan
dc.date.accessioned2018-02-12T17:14:38Z
dc.date.available2018-02-12T17:14:38Z
dc.identifier.urihttp://hdl.handle.net/10222/73604
dc.description.abstractProgrammed death ligand 1 (PD-L1) is a T cell inhibitory molecule expressed by activated T cells and antigen presenting cells, as well as by various tumor types. PD-L1 expression is believed to contribute to immune evasion by breast cancer cells. The goal of this investigation was to determine the effect of the phytochemical apigenin on PD-L1 expression by several breast cancer cell lines. Apigenin inhibited both IFN-?- and IFN-?-induced upregulation of PD-L1 by various breast cancer cell lines but did not affect constitutive PD-L1 expression. Apigenin also inhibited IFN-?-induced STAT1 phosphorylation. Apigenin-mediated reduction of IFN-?-induced PD-L1 expression by breast cancer cells increased Jurkat T cell proliferation in the presence of breast cancer cells. These data show that apigenin inhibits IFN-induced PD-L1 expression by breast cancer cells. Therefore, apigenin may act as an immunomodulator that increases the vulnerability of breast cancer cells to anti-tumor immune responses.en_US
dc.language.isoenen_US
dc.subjectApigeninen_US
dc.subjectProgrammed Death Ligand 1
dc.subjectImmunotherapy
dc.subjectBreast Cancer
dc.subjectT Cell
dc.titleThe Flavonoid Apigenin Inhibits Inducible Programmed Death Ligand 1 Expression by Breast Cancer Cellsen_US
dc.date.defence2012-07-23
dc.contributor.departmentDepartment of Microbiology & Immunologyen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinerDr. Robert Liwskien_US
dc.contributor.graduate-coordinatorDr. Roy Duncanen_US
dc.contributor.thesis-readerDr. Brent Johnstonen_US
dc.contributor.thesis-readerDr. Jun Wangen_US
dc.contributor.thesis-supervisorDr. David Hoskinen_US
dc.contributor.ethics-approvalNot Applicableen_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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