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dc.contributor.authorHeisler, Courtney
dc.date.accessioned2017-09-06T18:08:26Z
dc.date.available2017-09-06T18:08:26Z
dc.identifier.urihttp://hdl.handle.net/10222/73296
dc.description.abstractBackground: Bipolar disorder affects 2% of the Canadian population. Excluding family history, there have been no reliable indicators to identify who will develop the disorder. There has been little systematic study of the strength and timing of the association between clinical symptoms and mood episodes in high-risk individuals. Objective: To determine whether clinically significant childhood depressive and anxiety symptoms predicts the risk and age of onset of subsequent mood episodes. Methods: Clinically significant childhood anxiety and depressive symptoms and subsequent mood episodes were analyzed using discrete time survival analysis. Results: The study included 286 participants (40.7% male). Individuals with clinically significant symptoms were more likely to develop major mood episodes (HR=2.2, 1.2-3.9) and any diagnosable mood episode (HR=2.1, 1.2-3.7). Conclusions: Clinically significant symptoms were predictive of future mood episodes. By gaining greater insight into the natural trajectory of mood disorders, more focused identification and early intervention targets can take place.en_US
dc.language.isoenen_US
dc.subjectMood disordersen_US
dc.subjectClinically significant internalizing symptomsen_US
dc.subjectHigh-risken_US
dc.subjectFamily historyen_US
dc.subjectRisken_US
dc.subjectDepressive disordersen_US
dc.subjectBipolar disordersen_US
dc.titleMOOD AND ANXIETY SYMPTOMS: POTENTIAL RISK INDICATORS FOR MAJOR MOOD DISORDERS AMONG HIGH-RISK OFFSPRING OF BIPOLAR PARENTSen_US
dc.date.defence2017-08-18
dc.contributor.departmentDepartment of Community Health & Epidemiologyen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinerRoumen Mileven_US
dc.contributor.graduate-coordinatorKathleen MacPhersonen_US
dc.contributor.thesis-readerAnne Duffyen_US
dc.contributor.thesis-readerAdrian Levyen_US
dc.contributor.thesis-readerScott Pattenen_US
dc.contributor.thesis-readerKathleen McPhersonen_US
dc.contributor.thesis-supervisorAnne Duffyen_US
dc.contributor.thesis-supervisorAdrian Levyen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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