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dc.contributor.authorDeurveilher, Samuel
dc.contributor.authorRyan, Nathan
dc.contributor.authorBurns, Joan
dc.contributor.authorSemba, Kazue
dc.date.accessioned2016-09-27T13:59:12Z
dc.date.available2016-09-27T13:59:12Z
dc.date.issued2013-11-01
dc.identifier.citationThis is the peer reviewed manuscript version of the following article: Samuel Deurveilhera, Nathan Ryana, Joan Burnsa, Kazue Semba. (2013). Social and environmental contexts modulate sleep deprivation-induced c-Fos activation in rats. 256, 238–249. doi: 10.1016/j.bbr.2013.08.029en_US
dc.identifier.urihttp://hdl.handle.net/10222/72225
dc.identifier.urihttp://dx.doi.org/10.1016/j.bbr.2013.08.029
dc.description.abstractPeople often sleep deprive themselves voluntarily for social and lifestyle reasons. Animals also appear to stay awake longer as a result of their natural curiosity to explore novel environments and interact socially with conspecifics. Although multiple arousal systems in the brain are known to act jointly to promote and maintain wakefulness, it remains unclear whether these systems are similarly engaged during voluntary vs. forced wakefulness. Using c-Fos immunohistochemistry, we compared neuronal responses in rats deprived of sleep for 2 h by gentle sensory stimulation, exploration under social isolation, or exploration with social interaction, and rats under undisturbed control conditions. In many arousal, limbic, and autonomic nuclei examined (e.g., anterior cingulate cortex and locus coeruleus), the two sleep deprivation procedures involving exploration were similarly effective, and both were more effective than sleep deprivation with sensory stimulation, in increasing the number of c-Fos immunoreactive neurons. However, some nuclei (e.g., paraventricular hypothalamic nucleus and select amygdala nuclei) were more responsive to exploration with social interaction, while others (e.g., histaminergic tuberomammillary nucleus) responded more strongly to exploration in social isolation. In the rostral basal forebrain, cholinergic and GABAergic neurons responded preferentially to exploration with social interaction, whereas resident neurons in general responded most strongly to exploration without social interaction. These results indicate that voluntary exploration with/without social interaction is more effective than forced sleep deprivation with gentle sensory stimulation for inducing c-Fos in arousal and limbic/autonomic brain regions, and suggest that these nuclei participate in different aspects of arousal during sustained voluntary wakefulness.en_US
dc.description.sponsorshipCanadian Institutes of Health Research (MOP-93673; MOP-259183)en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (217301-2009)
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBehavioural Brain Researchen_US
dc.subjectSleep deprivation methoden_US
dc.subjectNovelty explorationen_US
dc.subjectSocial interactionen_US
dc.subjectArousalen_US
dc.subjectMotivationen_US
dc.subjectImmunohistochemistryen_US
dc.titleSocial and environmental contexts modulate sleep deprivation-induced c-Fos activation in ratsen_US
dc.typeManuscripten_US
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
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