| dc.contributor.author | Eelman, Melanie D. | en_US |
| dc.date.accessioned | 2014-10-21T12:38:50Z | |
| dc.date.available | 2004 | |
| dc.date.issued | 2004 | en_US |
| dc.identifier.other | AAINQ89802 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10222/54608 | |
| dc.description | In contrast to the toxicity displayed by many heavy metals, especially those in the p-block (e.g. lead, arsenic), bismuth compounds are well known for their therapeutic application in the treatment of gastrointestinal disorders and have a long history of medicinal use. Although the mechanisms of bioactivity are not understood, the thiophilicity of bismuth has prompted speculation that sulfur-containing biomolecules represent the primary target for pharmaceuticals such as 'colloidal bismuth subcitrate' and 'bismuth subsalicylate', the active ingredients of De-Nol RTM and Pepto-BismolRTM, respectively. However, definitive characterisation of bismuth and other heavy metal complexes involving biomolecules has been elusive. | en_US |
| dc.description | This work establishes the utility of electrospray ionisation mass spectrometry (ESI-MS) as a characterisation method to identify interactions of heavy metals with small biomolecules and other biorelevant ligands. In addition, the first examples of a bismuth and a lead complex involving amino acids have been isolated and structurally characterised. These observations provide important insight into how heavy metals, bioactive or otherwise, may become incorporated into biological systems. | en_US |
| dc.description | Thesis (Ph.D.)--Dalhousie University (Canada), 2004. | en_US |
| dc.language | eng | en_US |
| dc.publisher | Dalhousie University | en_US |
| dc.publisher | | en_US |
| dc.subject | Chemistry, Biochemistry. | en_US |
| dc.subject | Chemistry, Inorganic. | en_US |
| dc.title | Systematically developing the chemistry of bismuth and other heavy metals with biorelevant ligands. | en_US |
| dc.type | text | en_US |
| dc.contributor.degree | Ph.D. | en_US |
