dc.contributor.author | Moore, Jill Alexandra | |
dc.date.accessioned | 2014-08-06T11:49:51Z | |
dc.date.available | 2014-08-06T11:49:51Z | |
dc.date.issued | 2014-08-06 | |
dc.identifier.uri | http://hdl.handle.net/10222/53157 | |
dc.description.abstract | Reactivation of latent tuberculosis (TB) in HIV-infected individuals has arisen as a major contributor to early death in areas where TB and HIV overlap. CD4+ T cells are the targets of HIV, leading to insufficient IFN-γ to control disease. In the first section of this thesis I tested natural extracts to synergize with IFN-γ to control Mtb growth. Infected macrophages were treated with the extracts and IFN-γ. Although the extracts showed no synergy with IFN-γ, this model of ex vivo infection could provide a template for future study.
The second section investigated the contribution of pre-existing atherosclerosis to the development of allograft vasculopathy (AV). Aortas from ApoEKO mice bearing an atherosclerotic lesion were transplanted into fully disparate recipients, treated with Cyclosporin A and changes in size and structure were analyzed. The results support our hypothesis that by 7d changes in the atherosclerotic lesion post-transplant set the stage for AV. | en_US |
dc.language.iso | en | en_US |
dc.subject | innate immunity, macrophages, tuberculosis | en_US |
dc.subject | innate immunity, macrophages, atherosclerosis, cardiac transplantation | en_US |
dc.title | Implications of the Innate Immune Response in Tuberculosis and Cardiac Allograft Vasculopathy | en_US |
dc.date.defence | 2014-06-19 | |
dc.contributor.department | Department of Pathology | en_US |
dc.contributor.degree | Master of Science | en_US |
dc.contributor.external-examiner | Dr. Andrew Stadnyk | en_US |
dc.contributor.graduate-coordinator | Dr. Wenda Greer | en_US |
dc.contributor.thesis-reader | Dr. Greg Hirsch | en_US |
dc.contributor.thesis-reader | Dr. Laurette Geldenhuys | en_US |
dc.contributor.thesis-supervisor | Dr. Tim Lee | en_US |
dc.contributor.ethics-approval | Received | en_US |
dc.contributor.manuscripts | Not Applicable | en_US |
dc.contributor.copyright-release | Not Applicable | en_US |