Dalhousie Repository
The Exploration of Effect of Model Misspecification and Development of an Adequacy-Test for Substitution Model in Phylogenetics
DalSpace/Manakin Repository
JavaScript is disabled for your browser. Some features of this site may not work without it.
| dc.contributor.author | Chen, Wei Jr | |
| dc.date.accessioned | 2012-11-16T13:15:21Z | |
| dc.date.available | 2012-11-16T13:15:21Z | |
| dc.date.issued | 2012-11-16 | |
| dc.identifier.uri | http://hdl.handle.net/10222/15705 | |
| dc.description.abstract | It is possible that the maximum likelihood method can give an inconsistent result when the DNA sequences are generated under a tree topology which is in the Felsentein Zone and analyzed with a misspeci ed model. Therefore, it is important to select a good substitution model. This thesis rst explores the e ects of di erent degrees and types of model misspeci cation on the maximum likelihood estimates. The results are presented for tree selection and branch length estimates based on simulated data sets. Next, two Pearson's goodness-of- t tests are developed based on binning of site patterns. These two tests are used for testing the adequacy of substitution models and their performances are studied on both simulated data sets and empirical data. | en_US |
| dc.language.iso | en_US | en_US |
| dc.subject | model misspecification | en_US |
| dc.subject | statistical test | en_US |
| dc.title | The Exploration of Effect of Model Misspecification and Development of an Adequacy-Test for Substitution Model in Phylogenetics | en_US |
| dc.date.defence | 2012-11-06 | |
| dc.contributor.department | Department of Mathematics & Statistics - Statistics Division | en_US |
| dc.contributor.degree | Master of Science | en_US |
| dc.contributor.external-examiner | n/a | en_US |
| dc.contributor.graduate-coordinator | Dr. David Hamilton | en_US |
| dc.contributor.thesis-reader | Dr. Edward Susko | en_US |
| dc.contributor.thesis-reader | Dr. Toby Kenney | en_US |
| dc.contributor.thesis-supervisor | Dr. Hong Gu and Dr. Joseph Bielawski | en_US |
| dc.contributor.ethics-approval | Not Applicable | en_US |
| dc.contributor.manuscripts | Not Applicable | en_US |
| dc.contributor.copyright-release | Not Applicable | en_US |
