Now showing items 1-20 of 98

  • Permeation of losartan across human respiratory epithelium: an in vitro study with Calu-3 cells 

    Amoako-Tuffour, M., P. K. Yeung, and R. U. Agu. 2009. "Permeation of losartan across human respiratory epithelium: an in vitro study with Calu-3 cells." Acta pharmaceutica (Zagreb, Croatia) 59(4): 395-405.
    The potential for nasal delivery of losartan, a drug with poor oral bioavailability, was investigated using Calu-3 cells. Epithelial permeation of the drug with or without dimethyl-beta-cyclodextrin (DM-beta-CD) and ...
  • Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function 

    Mak, M. C., K. M. Lam, P. K. Chan, Y. B. Lau, et al. 2011. "Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function." PloS one 6(7): 19186.
    Nuclear factor of activated T cells 5 protein (NFAT5) is thought to be important for cellular adaptation to osmotic stress by regulating the transcription of genes responsible for the synthesis or transport of organic ...
  • Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury 

    Mak, K. M., A. C. Lo, A. K. Lam, P. K. Yeung, et al. 2012. "Nuclear factor of activated T cells 5 deficiency increases the severity of neuronal cell death in ischemic injury." Neuro-Signals 20(4): 237-251.
    Nuclear factor of activated T cells 5 (NFAT5) has been implicated in regulating several genes that are thought to be neuroprotective in ischemic injury. Because of the embryonic lethality of NFAT5 knockout (NFAT5(-/-)) ...
  • Gender Differences in Diltiazems Action to Lower Blood-Pressure 

    KLASSEN, GA, PK YEUNG, KD BARCLAY, OR HUNG, et al. 1994. "Gender Differences in Diltiazems Action to Lower Blood-Pressure." Circulation 90(4): 505-505.
    No abstract available.
  • Enantiomerically Pure Metabolites of Diltiazem 

    LIU, Y., R. LI, PS FARMER, PKF YEUNG, et al. 1994. "Enantiomerically Pure Metabolites of Diltiazem." Abstracts of Papers of the American Chemical Society 207: 264-MEDI.
    No abstract available.
  • Synthesis and Characterization of Diltiazem Metabolites 

    LI, RS, PS FARMER, M. QUILLIAM, and PKF YEUNG. 1991. "Synthesis and Characterization of Diltiazem Metabolites." Abstracts of Papers of the American Chemical Society 202: 129-MEDI.
    No abstract available.
  • Gender differences in exercise and recovery blood pressure responses in normal volunteers given diltiazem 

    Klassen, GA, PFK Yeung, KD Barclay, OR Hung, et al. 1995. "Gender differences in exercise and recovery blood pressure responses in normal volunteers given diltiazem." Journal of clinical pharmacology 35(12): 1144-1149.
    This preliminary phase I study was conducted in healthy volunteers to determine whether gender differences exist in the hemodynamic effects of diltiazem at rest, during exercise, and after exercise. At comparable serum ...
  • Synthesis, characterization, and Ca2+ antagonistic activity of diltiazem metabolites 

    Li, R., P. S. Farmer, M. Xie, M. A. Quilliam, et al. 1992. "Synthesis, characterization, and Ca2+ antagonistic activity of diltiazem metabolites." Journal of medicinal chemistry 35(17): 3246-3253.
    Diltiazem is a calcium antagonist widely used in the treatment of angina and hypertension. The contributions of metabolites of diltiazem to the vasorelaxant effects of diltiazem were investigated. The synthesis and ...
  • Cyclic ADP-ribose links metabolism to multiple fission in the dinoflagellate Crypthecodinium cohnii 

    Lam, C. M., P. K. Yeung, H. C. Lee, and J. T. Wong. 2009. "Cyclic ADP-ribose links metabolism to multiple fission in the dinoflagellate Crypthecodinium cohnii." Cell calcium 45(4): 346-357.
    Cellular metabolism is required for cell proliferation. However, the way in which metabolic signals are conveyed to cell cycle decisions is unclear. Cyclic ADP-ribose (cADPR), the NAD(+) metabolite, mobilizes calcium ...
  • Cladribine inhibits a diltiazem-induced increase in red blood cell purine nucleotide concentrations in a zebrafish model 

    Klein, Lauren C., Pollen K. Yeung, and Jason N. Berman. 2009. "Cladribine inhibits a diltiazem-induced increase in red blood cell purine nucleotide concentrations in a zebrafish model." Biomarkers 14(8): 554-559.
    Minimizing drug interactions is paramount to improving the efficacy and tolerability of cancer therapy. The zebrafish represents an innovative cancer model due to highly conserved genetics and inherent capacity for ...
  • Monitoring cytosolic calcium in the dinoflagellate Crypthecodinium cohnii with calcium orange-AM 

    Lam, C. M., P. K. Yeung, and J. T. Wong. 2005. "Monitoring cytosolic calcium in the dinoflagellate Crypthecodinium cohnii with calcium orange-AM." Plant & cell physiology 46(6): 1021-1027.
    Calcium plays several important roles in the signal transduction pathways of dinoflagellates. We describe here the development of calcium orange-AM as an intracellular calcium reporter for the heterotrophic dinoflagellate ...
  • Universal intermittent properties of particle trajectories in highly turbulent flows 

    Arneodo, A., R. Benzi, J. Berg, L. Biferale, et al. 2008. "Universal intermittent properties of particle trajectories in highly turbulent flows." Physical Review Letters 100(25): 254504.
    We present a collection of eight data sets from state-of-the-art experiments and numerical simulations on turbulent velocity statistics along particle trajectories obtained in different flows with Reynolds numbers in the ...
  • Pharmacokinetics and metabolism of diltiazem in rats following a single intra-arterial or single oral dose 

    Tsui, B. C., J. D. Feng, S. J. Buckley, and P. K. Yeung. 1994. "Pharmacokinetics and metabolism of diltiazem in rats following a single intra-arterial or single oral dose." European journal of drug metabolism and pharmacokinetics 19(4): 369-373.
    Diltiazem (DTZ) 20 mg/kg was given to male Sprague-Dawley rats either orally (p.o.) or intra-arterially (i.a.) over a 5 min period (n = 6 for each group). Plasma concentrations of DTZ and its major basic metabolites were ...
  • Pharmacokinetics and haemodynamic effect of diltiazem in rats: effect of route of administration 

    Tsui, B. C., J. D. Feng, and P. K. Yeung. 1998. "Pharmacokinetics and haemodynamic effect of diltiazem in rats: effect of route of administration." The Journal of pharmacy and pharmacology 50(2): 183-188.
    Diltiazem is a calcium antagonist widely used for the treatment of angina and hypertension. Previous studies in patients have shown that the haemodynamic effects of diltiazem are greater after parenteral rather than oral ...
  • A reliable technique for chronic carotid arterial catheterization in the rat 

    Tsui, B. C., S. J. Mosher, and P. K. Yeung. 1991. "A reliable technique for chronic carotid arterial catheterization in the rat." Journal of pharmacological methods 25(4): 343-352.
    A reliable and simple method for cannulating the carotid artery of rats is described. The rat was anesthetized with halothane. The right carotid artery located between the omohyoideus and sternohyoideus muscles was exposed ...
  • Effect of doxorubicin on cardiovascular hemodynamic and RBC concentrations of ATP in rats in vivo 

    Starr, L., C. Purcell, and P. K. F. Yeung. 2012. "Effect of doxorubicin on cardiovascular hemodynamic and RBC concentrations of ATP in rats in vivo." Current Topics in Pharmacology 16(1): 59-65.
    The cardiovascular effect of doxorubicin (DOX) was investigated in a Sprague Dawley (SD) rat model in vivo which allowed continuous cardiovascular hemodynamic monitoring, and serial blood sample collection for measurement ...
  • Development and validation of the Chinese version of the Reintegration to Normal Living Index for use with stroke patients 

    Pang, M. Y., R. W. Lau, P. K. Yeung, L. R. Liao, et al. 2011. "Development and validation of the Chinese version of the Reintegration to Normal Living Index for use with stroke patients." Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine 43(3): 243-250.
    OBJECTIVE: To develop and validate a Chinese version of the Reintegration to Normal Living Index. DESIGN: Descriptive case-series. SUBJECTS: Seventy-five individuals with chronic stroke and 55 age-matched healthy subjects. ...
  • Therapeutic monitoring of chlorpromazine IV: Comparison of a new high-performance liquid chromatographic method with radioimmunoassays for parent drug and some of its major metabolites 

    Midha, K. K., J. W. Hubbard, J. K. Cooper, T. Gurnsey, et al. 1987. "Therapeutic monitoring of chlorpromazine IV: Comparison of a new high-performance liquid chromatographic method with radioimmunoassays for parent drug and some of its major metabolites." Therapeutic drug monitoring 9(3): 358-365.
    A new high-performance liquid chromatographic (HPLC) procedure for the simultaneous determination of chlorpromazine and its six metabolites, namely, 7-hydroxy-chlorpromazine, N-monodesmethyl-chlorpromazine, 7-hydroxy- ...
  • Radioimmunoassay for trifluoperazine in human plasma 

    Midha, K. K., J. W. Hubbard, J. K. Cooper, E. M. Hawes, et al. 1981. "Radioimmunoassay for trifluoperazine in human plasma." British journal of clinical pharmacology 12(2): 189-193.
    1 A new sensitive and rapid radioimmunoassay procedure for the determination of the plasma concentrations of the neuroleptic drug trifluoperazine is described. 2 The antiserum developed for trifluoperazine cross-reacted ...