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CHARACTERIZATION AND DEVELOPMENT OF THE M2 MELANOPSIN RETINAL GANGLION CELL IN THE CLM-1 TRANSGENIC MOUSE RETINA

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dc.contributor.author Husain, Sahira Fathima
dc.date.accessioned 2012-09-06T12:15:13Z
dc.date.available 2012-09-06T12:15:13Z
dc.date.issued 2012-09-06
dc.identifier.uri http://hdl.handle.net/10222/15463
dc.description.abstract Retinal ganglion cells (RGCs) undergo continued maturation after birth. RGC development can be influenced by light, but for most RGCs this requires the development of functional retinal circuits that occurs up to 2 weeks after birth. A subpopulation of RGCs express melanopsin (MRGCs) making them intrinsically photosensitive at birth. I hypothesized that this intrinsic photosensitivity could affect the morphology of MRGCs during the postnatal (PN) developmental period (PN 3 to adult). I took advantage of the Clomeleon-expressing transgenic mouse line that, combined with melanopsin immunohistochemistry, allowed for the systematic identification of the M2 MRGC at different PN periods. The pattern of development of the M2 MRGC, characterized through the analysis of 6 morphological parameters, was similar to that described for other types of RGCs. Thus, despite being intrinsically photosensitive, M2 MRGCs did not show substantial developmental differences from other RGC types en_US
dc.language.iso en en_US
dc.subject vision en_US
dc.subject retina en_US
dc.subject retinal ganglion cells en_US
dc.subject melanopsin en_US
dc.subject development en_US
dc.title CHARACTERIZATION AND DEVELOPMENT OF THE M2 MELANOPSIN RETINAL GANGLION CELL IN THE CLM-1 TRANSGENIC MOUSE RETINA en_US
dc.date.defence 2012-08-20
dc.contributor.department Department of Clinical Vision Science en_US
dc.contributor.degree Master of Science en_US
dc.contributor.external-examiner Kevin Duffy en_US
dc.contributor.graduate-coordinator Karen McMain en_US
dc.contributor.thesis-reader Balwantray Chauhan en_US
dc.contributor.thesis-reader Francois Tremblay en_US
dc.contributor.thesis-supervisor William Baldridge en_US
dc.contributor.ethics-approval Received en_US
dc.contributor.manuscripts Not Applicable en_US
dc.contributor.copyright-release Not Applicable en_US


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