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Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells
(International Journal of Cancer, 2011-11-02)
Resistance of carcinoma cells to anoikis, apoptosis that is normally induced by detachment of non-malignant epithelial cells from the extracellular matrix, is thought to be critical for carcinoma progression. Molecular ...
John P. Finley (Draft Profile)
Kirill Rosen (Draft Profile)
Oncogenic ras-induced downregulation of a pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells
(Journal of Biological Chemistry, 2011-11-11)
Resistance of carcinoma cells to anoikis, apoptosis that is normally induced by loss of cell-to-extracellular matrix (ECM) adhesion, is thought to be essential for the ability of these cells to form primary tumors, invade ...