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dc.contributor.authorRoddick, Kyle
dc.date.accessioned2012-08-17T14:52:56Z
dc.date.available2012-08-17T14:52:56Z
dc.date.issued2012-08-17
dc.identifier.urihttp://hdl.handle.net/10222/15269
dc.description.abstractUsing an operant-olfactometer, the long term learning and memory, executive function, olfactory sensitivity, and working memory of the 5XFAD mouse model of Alzheimer’s disease was assessed. Six month old male and female 5XFAD and wildtype mice were tested. No deficits were found on an olfactory discrimination task or a reversal learning task. Female and transgenic mice performed better than male and wildtype mice on the higher odour concentrations, but not the lower concentrations, of the sensitivity task, suggesting differences in learning rate or maximum performance on the task, but not olfactory detection. This study demonstrated for the first time that mice are able to learn an olfactory delayed matching to sample task with delays up to 30 seconds long. Female mice showed higher levels of performance on the matching to sample task than male mice, indicative of better working memory.en_US
dc.language.isoenen_US
dc.subject5XFADen_US
dc.subjectAlzheimer’s Diseaseen_US
dc.subjectLearning and Memoryen_US
dc.subjectOlfactionen_US
dc.subjectMiceen_US
dc.subjectWorking Memoryen_US
dc.titleAssessing Olfactory Learning and Memory in the 5XFAD Mouse Model of Alzheimer’s Diseaseen_US
dc.date.defence2012-07-24
dc.contributor.departmentDepartment of Psychology with Neuroscienceen_US
dc.contributor.degreeMaster of Scienceen_US
dc.contributor.external-examinerNAen_US
dc.contributor.graduate-coordinatorDr Tracy Taylor-Helmicken_US
dc.contributor.thesis-readerDr Victor Rafuseen_US
dc.contributor.thesis-supervisorDr Heather Schellinck & Dr Richard Brownen_US
dc.contributor.ethics-approvalReceiveden_US
dc.contributor.manuscriptsNot Applicableen_US
dc.contributor.copyright-releaseNot Applicableen_US
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