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Quantitative Magnetic Resonance Imaging of Cellular Density with TurboSPI

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dc.contributor.author Rioux, James
dc.date.accessioned 2012-08-14T12:27:18Z
dc.date.available 2012-08-14T12:27:18Z
dc.date.issued 2012-08-14
dc.identifier.uri http://hdl.handle.net/10222/15229
dc.description.abstract Magnetic Resonance Imaging can now detect cells that are labeled with contrast agents such as superparamagnetic iron oxide (SPIO). Quantitative monitoring, which is desirable for evaluating cellular therapies, remains challenging. In this work, an MRI technique called TurboSPI is implemented for quantitative cellular imaging. TurboSPI acquires maps of the relaxation rate R2', which is directly related to SPIO concentration. Quantification of R2' is demonstrated using micron-sized iron oxide particles and SPIO-labeled cells. To explain experimental results that deviated from predicted behavior, an extended analytical description of MRI signal relaxation near SPIO was developed. This model compares well to Monte Carlo simulations and experimental data, and may allow improved quantification. The slow imaging speed of TurboSPI is overcome using a signal processing technique called compressed sensing to reconstruct undersampled data, enabling in vivo animal imaging with TurboSPI. Such images demonstrate detection of iron with improved specificity and good potential for quantification. en_US
dc.language.iso en en_US
dc.subject Magnetic Resonance Imaging en_US
dc.subject Cellular Imaging en_US
dc.subject Quantitative Imaging en_US
dc.subject MR Relaxometry en_US
dc.subject Compressed Sensing en_US
dc.title Quantitative Magnetic Resonance Imaging of Cellular Density with TurboSPI en_US
dc.date.defence 2012-08-01
dc.contributor.department Department of Physics & Atmospheric Science en_US
dc.contributor.degree Doctor of Philosophy en_US
dc.contributor.external-examiner Dr. Blaine Chronik en_US
dc.contributor.graduate-coordinator Dr. Randall Martin en_US
dc.contributor.thesis-reader Dr. Steven Beyea en_US
dc.contributor.thesis-reader Dr. Laurent Kreplak en_US
dc.contributor.thesis-supervisor Dr. Chris Bowen, Dr. Kevin Hewitt en_US
dc.contributor.ethics-approval Not Applicable en_US
dc.contributor.manuscripts Not Applicable en_US
dc.contributor.copyright-release Not Applicable en_US

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