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Development and validation of a sensitive and specific HPLC assay of cladribine for pharmacokinetics studies in rats
PURPOSE: To develop and validate a sensitive and specific HPLC assay for cladribine (CdA) in plasma for pharmacokinetic studies in rats. METHODS: CdA and the internal standard AZT were purchased from Sigma-Aldrich Chem. ...
Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans
Streptococcus mutans secretes and utilizes a 21-amino-acid signaling peptide pheromone to initiate quorum sensing for genetic competence, biofilm formation, stress responses, and bacteriocin production. In this study, we ...