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CHARACTERIZATION OF THE ANGIOTENSIN TYPE 1 RECEPTOR AND THE BETA2 ADRENERGIC RECEPTOR PROPERTIES: THE INVOLVEMENT OF ARRESTIN2, RAB1 AND SOME MOLECULAR CHAPERONES IN THE ASSEMBLY AND TRAFFICKING OF GPCRS

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dc.contributor.author Hammad, Maha
dc.date.accessioned 2010-09-10T19:02:43Z
dc.date.available 2010-09-10T19:02:43Z
dc.date.issued 2010-09-10
dc.identifier.uri http://hdl.handle.net/10222/13068
dc.description.abstract Current drugs used to treat Congestive Heart Failure target the renin-angiotensin and adrenergic systems. Studies showed increased mortality rates in patients treated with a combination of these medications. Angiotensin-AT1 and ?2-Adrenergic receptors were shown to form receptor heteromers. Blockade of one receptor in the complex can affect the signal transmitted by the other; suggesting that ligand-based therapy is not as selective as we might think. Modulating receptor trafficking after synthesis might prove to be a valid therapeutic strategy. Unfortunately, little is known about receptor assembly and transport from Endoplasmic Reticulum to Plasma Membrane. The objectives of this study are to identify the proteins that participate in the assembly of AT1R-?2AR heteromer and the regulators of the anterograde trafficking of G-Protein Coupled Receptors. This thesis introduces the role of important targets in those poorly understood processes. The identification of such targets could lead to developing better drugs with fewer adverse effects. en_US
dc.language.iso en_US en_US
dc.subject G Protein Coupled Receptors en_US
dc.subject Congestive Heart Failure en_US
dc.subject Adrenergic Receptors en_US
dc.subject Angiotensin Receptors en_US
dc.subject Rab GTPases en_US
dc.subject Molecular Chaperones en_US
dc.subject Bimolecular Fluorescence Complementation en_US
dc.subject GPCRs Oligomerization en_US
dc.title CHARACTERIZATION OF THE ANGIOTENSIN TYPE 1 RECEPTOR AND THE BETA2 ADRENERGIC RECEPTOR PROPERTIES: THE INVOLVEMENT OF ARRESTIN2, RAB1 AND SOME MOLECULAR CHAPERONES IN THE ASSEMBLY AND TRAFFICKING OF GPCRS en_US
dc.date.defence 2010-07-21
dc.contributor.department Department of Pharmacology en_US
dc.contributor.degree Master of Science en_US
dc.contributor.external-examiner Dr. Stefan Krueger en_US
dc.contributor.graduate-coordinator Dr. Eileen Denovan-Wright en_US
dc.contributor.thesis-reader Dr. Christopher Sinal en_US
dc.contributor.thesis-supervisor Dr. Denis Dupre en_US
dc.contributor.ethics-approval Not Applicable en_US
dc.contributor.manuscripts Not Applicable en_US
dc.contributor.copyright-release Yes en_US


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