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Isolation of Lead-Amino Acid and Mercury-Amino Acid Complexes with Characterization in the Solid State, the Solution State, and the Gas Phase

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dc.contributor.author Saunders, Cheryl D.L.
dc.date.accessioned 2009-10-16T12:16:26Z
dc.date.available 2009-10-16T12:16:26Z
dc.date.issued 2009-10-16T12:16:26Z
dc.identifier.uri http://hdl.handle.net/10222/12228
dc.description.abstract Although some physiological effects of toxic metal poisoning have been known for centuries, the specific chemical interactions between biological molecules and mercury(I), mercury(II) or lead(II) are not well understood. To date, only thirteen crystal structures of inorganic mercury-amino acid complexes and six crystal structures of lead-amino acid complexes have been reported with varying degrees of characterization. In order to improve our understanding of the coordination chemistry of mercury and lead in biological environments, a systematic method for the isolation of inorganic metal-amino acid complexes from acidic aqueous solutions has been developed. With this method we have prepared five new lead-amino acid complexes (with L-valine, L-isoleucine, L-phenylalanine, and L-arginine) and four new mercury-amino acid complexes (with L-alanine, D-alanine, L-proline, and N-methyl-L-alanine). These metal-amino acid complexes have been comprehensively characterized in the solid state, solution state and gas phase. The development of this isolation technique in conjunction with the exploration of a number of characterization techniques for studying metal-amino acid interactions greatly enhances the known methods by which metal-biological molecule systems are studied. en_US
dc.language.iso en en_US
dc.subject Chemistry, lead, mercury, amino acids, ESI-MS, NMR, X-ray crystallography en_US
dc.title Isolation of Lead-Amino Acid and Mercury-Amino Acid Complexes with Characterization in the Solid State, the Solution State, and the Gas Phase en_US
dc.date.defence 2009-08-11
dc.contributor.department Department of Chemistry en_US
dc.contributor.degree Doctor of Philosophy en_US
dc.contributor.external-examiner Scott Bohle en_US
dc.contributor.graduate-coordinator Robert L. White en_US
dc.contributor.thesis-reader Alan A. Doucette en_US
dc.contributor.thesis-reader Kevin R. Grundy en_US
dc.contributor.thesis-reader James A. Pincock en_US
dc.contributor.thesis-supervisor Neil Burford en_US
dc.contributor.ethics-approval Not Applicable en_US
dc.contributor.manuscripts Not Applicable en_US
dc.contributor.copyright-release Not Applicable en_US


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