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NUTRIENT REGULATION OF AUTOPHAGY IN THE HEART
(2016-09-02)
Impaired cardiac metabolism in the obese-diabetic heart leads to glucolipotoxicity and ensuing cardiomyopathy. Glucolipotoxicity causes cardiomyocyte injury by increasing energy insufficiency and by dysregulating proteolysis. ...
Role of Transcription Factor EB in obesity mediated cardiac dysfunction
(2023-08-21)
Lipotoxic complications drive impairment in cardiac function during obesity. Specifically, palmitate toxicity induces ER stress, calcium mishandling and perturbations in lysosomal function by downregulating transcription ...