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CHEMERIN REGULATES ADIPOSITY AND ENERGY HOMEOSTASIS
(2011-11-08)
Obesity, characterized by an excess of adipose tissue, is an established risk factor
for cardiovascular disease and type II diabetes. Different mechanisms linking obesity with
these comorbidities have been postulated but ...
THE ROLE OF LYSOPHOSPHATIDIC ACID AND AUTOTAXIN IN OBESITY-INDUCED CARDIAC INSULIN RESISTANCE
(2017-08-09)
The metabolic changes to adipose tissue during obesity can induce cardiac insulin resistance. During obesity and diabetes, cardiac metabolic flexibility is reduced, which may lead to impaired ATP production, elevated ...
NUTRIENT REGULATION OF AUTOPHAGY IN THE HEART
(2016-09-02)
Impaired cardiac metabolism in the obese-diabetic heart leads to glucolipotoxicity and ensuing cardiomyopathy. Glucolipotoxicity causes cardiomyocyte injury by increasing energy insufficiency and by dysregulating proteolysis. ...
The role of secretion associate ras-related GTPase 1b in skeletal muscle insulin signaling
(2023-04-24)
Dysfunctional branched-chain amino acid (BCAA) catabolism increases intracellular branched-chain keto acids (BCKA), which inhibit insulin signaling. The discovery of Secretion Associated Ras-related GTPase-1B (Sar1b), a ...