Browsing Faculty of Graduate Studies Online Theses by Subject "Inflammation"
Now showing items 1-20 of 20
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Anti-inflammatory properties of potato protein hydrolysates in cellular and animal models
(2014-12-17)Inflammation is a series of non-specific immune responses and irregular inflammation can lead to injury and chronic diseases such as cardiovascular diseases. TNF-α is one of the primary pro-inflammatory cytokines mediating ... -
Beta-Caryophyllene - A Novel Adjunct Treatment For Bacterial Cystitis in Mice
(2022-04-27)Bacterial cystitis (BC) belongs to the family of urinary tract infections (UTIs) and represents one of the most common types of infections. BC occurs when uropathogenic bacteria, mainly Escherichia coli (UPEC), enters the ... -
CANNABINOID 2 RECEPTOR AND GPR55 AS THERAPEUTIC TARGETS IN EXPERIMENTAL SEPSIS
(2017-09-15)Sepsis represents a dysregulated systemic acute inflammatory response to severe infection. Despite efforts to develop supportive sepsis therapies, none has been approved that address the immune dysregulation. The endogenous ... -
Characterization of anti-inflammatory, anti-Streptococcus pyogenes and anti-biofilm activities of summer savory phytochemicals
(2015)Streptococcus pyogenes is a common cause of sore throat that requires clinical intervention. Antibiotics and non-steroidal anti-inflammatory drugs are often prescribed to inhibit the growth of bacteria and relieve pain, ... -
DELVING INTO THE HEART OF THE MATTER: UNDERSTANDING THE ASSOCIATIONS BETWEEN TGF-β, CTGF AND EARLY MYOCARDIAL CHANGES IN ANGIOTENSIN-II INDUCED MYOCARDIAL FIBROSIS
(2017-03-31)Myocardial fibrosis is the common pathophysiological complication associated with diastolic heart failure. It is characterized by excess extracellular matrix (ECM) protein deposition, which contributes to increased ... -
Dietary supplementation of haskap berry (Lonicera caerulea L.) anthocyanin-rich fraction and probiotics attenuates the severity of dextran sulfate sodium-induced acute colitis in Balb/C mice
(2023-04-14)Haskap (Lonicera caerulea L.) berry is a rich dietary source of anthocyanins with anti-inflammatory properties. This study aimed at investigating the supplementation of haskap anthocyanin-rich fraction alone or with ... -
Experimental Cannabinoid Receptor 2 Activation in Lipopolysaccharide-Induced Interstitial Cystitis in Mice
(2020-12-18)Interstitial cystitis (IC) is a chronic pain disorder of the urinary bladder that causes symptoms of persistent pelvic pain, nocturia, and dysuria with no curative treatment. Medical management is therefore directed toward ... -
Maternal Microbes: The Effects of Probiotic Treatment on Maternal Care Behaviour, Inflammation and Offspring Stress Outcomes
(2019-08-16)Active maternal care is vital in offspring stress programming, yet the behaviour of a mother towards her offspring can also be influenced by her external environment. It is essential to understand what impacts maternal ... -
MICROGLIA RESPONSES IN A RAT MODEL OF CHRONIC SLEEP RESTRICTION
(2020-08-27)Recent research suggests that the brain and body adapt to chronic sleep restriction (CSR) resulting in only modest attempts to recover lost sleep and negatively impacting health over time. Microglia, the immune cells of ... -
MITOCHONDRIAL DAMAGE-ASSOCIATED MOLECULAR PATTERNS IMPACT LYMPHOCYTE FUNCTION AND CORRELATE WITH ORGAN HEALTH DURING NORMOTHERMIC MACHINE PERFUSION
(2024-02-06)Damage-associated molecular pattern (DAMP) molecules from mitochondria (mitoDAMPs) are released following tissue injury. Innate immune cells promote inflammation in response to mitoDAMPs, yet how this is controlled and ... -
Modulation of Acute Lung Injury-Associated Systemic Inflammation by the Cannabinoid Type 2 Receptor Agonist HU-308
(2024-07-09)Acute lung injury (ALI), clinically diagnosed as acute respiratory distress syndrome (ARDS), is a severe inflammatory syndrome characterized by pulmonary edema and refractory hypoxemia. Many patients with ARDS succumb to ... -
MODULATION OF IMMUNE FUNCTION AND PROMOTION OF RESTORATIVE GENE EXPRESSION BY AF4 IN A MOUSE MODEL OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2014-02-25)The anti-inflammatory and restorative effects of the flavonoid-enriched fraction AF4 were examined in a mouse model of experimental autoimmune encephalomyelitis (EAE). Relative to EAE mice that received vehicle (water, 10 ... -
Phytosomal Beta-Caryophyllene for the Treatment of Pain and Inflammation in Interstitial Cystitis
(2024-06-27)Interstitial cystitis (IC) is a chronic bladder condition of unknown etiology characterized by pain and inflammation. This study examined the effects of oral phytosomal beta-caryophyllene (BCP), a cannabinoid type 2 receptor ... -
PIOGLITAZONE IS SUPERIOR TO QUETIAPINE, CLOZAPINE AND TAMOXIFEN AT ALLEVIATING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2018-07-03)Recent evidence suggests that clozapine, quetiapine, tamoxifen and pioglitazone may improve functional recovery in multiple sclerosis (MS). We have compared the effectiveness of oral administration of these drugs, beginning ... -
Probiotics, Pregnancy and The Postpartum Period: Effects of Diet and Probiotic Treatment on Maternal and Offspring Health Outcomes in a Long-Evans Rat Model
(2024-08-28)The Developmental Origins of Health and Disease hypothesis is largely focused on elucidating the mechanisms by which gestational events affect offspring health. This area of research has recently begun examining the interplay ... -
Protective Ventilation vs. Hypercapnia for the Attenuation of Ventilator-Associated Lung Injury
(2011-09-06)Mechanically ventilated patients are at risk of developing Ventilator-Associated Lung Injury (VALI). Improved ventilation strategies by lung-protective settings may cause hypercapnia. This study investigated whether ... -
REGULATION OF INFLAMMATION, LUNG INJURY AND AUTOPHAGY DURING PSEUDOMONAS AERUGINOSA LUNG INFECTION
(2016-04-29)Pseudomonas aeruginosa is an opportunistic bacterial pathogen which causes acute and chronic infections in immune compromised individuals, including cystic fibrosis (CF) patients where it represents the leading cause of ... -
Role of Iron Chelation in Inflammation and Infection
(2021-09-14)Iron is an essential element for most forms of life, as its redox-cycling capabilities enable its participation in numerous physiological reactions. However, iron levels must be tightly regulated to avoid free iron toxicity ... -
The role of mast cells and toll-like receptor 2 (TLR2) in host defence and pathology following Chlamydia infection
(2019-01-15)Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection and the leading cause of infectious blindness worldwide. A comprehensive understanding of immune responses to Ct, and how they lead to ... -
Tumor necrosis factor-{alpha} amplifies adipose-derived chemerin production and bioactivation
(2013-03-20)Due to its escalating prevalence, obesity is becoming a leading cause of morbidity and mortality worldwide. Obesity is a complex health problem accompanied by metabolic abnormalities and low-grade inflammation that increases ...