Browsing Faculty of Graduate Studies Online Theses by Title
Now showing items 928-947 of 7892
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CHARACTERIZATION OF SOCIAL DEFICITS IN THE 5XFAD MOUSE MODEL OF ALZHEIMER'S DISEASE
(2019-11-28)The 5xFAD mouse strain is a double-transgenic Alzheimer’s disease (AD) model containing mutant APP (K670N/M671L, I716V, and V717I) and PS1 (M146L and L286V) genes. Mice expressing these mutations have rapid accumulation ... -
Characterization of Structural and Functional Properties of Class IB Hydrophobins
(2020-08-07)Hydrophobins are low molecular weight self-assembling proteins secreted by fungi and are active at hydrophobic-hydrophilic interfaces. Hydrophobins may undergo structural rearrangement and oligomerize to form rodlets, ... -
CHARACTERIZATION OF THE ANGIOTENSIN TYPE 1 RECEPTOR AND THE BETA2 ADRENERGIC RECEPTOR PROPERTIES: THE INVOLVEMENT OF ARRESTIN2, RAB1 AND SOME MOLECULAR CHAPERONES IN THE ASSEMBLY AND TRAFFICKING OF GPCRS
(2010-09-10)Current drugs used to treat Congestive Heart Failure target the renin-angiotensin and adrenergic systems. Studies showed increased mortality rates in patients treated with a combination of these medications. Angiotensin-AT1 ... -
Characterization of the Arabidopsis thaliana RING-type Ubiquitin Ligase XBAT31.1 and its Role in Response to Iron Deficiency Stress
(2019-11-28)Iron (Fe) is a very important micronutrient, specially for animals and plants. In humans, Fe-deficiency can cause anemia, which affects 43% of children, 38% of pregnant woman and 29% of non-pregnant women (World Health ... -
Characterization of the Cannabis Terpene Myrcene in Joint Pain and Inflammation in a Rat Model of Rheumatoid Arthritis
(2021-01-28)Rheumatoid arthritis is a progressive inflammatory condition resulting in joint damage and debilitating pain. Current treatments present with variable efficacy and negative side effects, leaving pain management a priority. ... -
Characterization of the Diet-Microbiota-Gut-Brain Axis and its Role in Neuroinflammation
(2022-09-01)Neurodegenerative Diseases (NDs) are the leading causes of disability/death globally. The Diet-Microbiota-Gut-Brain (DMGB) axis is a promising area of research for NDs, investigating how intercommunication between diet, ... -
Characterization of the Early Cellular Mechanisms Promoting Myocardial Fibrosis
(2012-08-17)Myocardial fibrosis is a common pathological finding in patients with cardiovascular disease and is believed to be a major contributing factor in the development of end stage organ failure. Early events that promote the ... -
Characterization of the effects of RACK1 expression on mitochondrial physiology
(2023-07-31)Receptor for activated C kinase 1 (RACK1) is a multifunctional scaffolding protein that coordinates a variety of fundamental cellular processes in eukaryotic cells, and its aberrant expression has been implicated in the ... -
Characterization of the gene encoding a 40 kDa major antigen of the sealworm (Pseudoterranova decipiens).
(Dalhousie University, 1994) -
Characterization of the Interaction of Alpha4 Phosphoprotein with Novel Binding Partners: EDD E3 Ubiquitin Ligase and Poly(A)-Binding Protein
(2011-04-08)?4 phosphoprotein (also known as IGBP1) is a component of the mammalian target-of-rapamycin (mTOR) pathway that controls the initiation of translation and cell-cycle progression in response to nutrients and growth factors. ... -
Characterization of the Low- and High-Velocity Impact Performances of Fiber Reinforced Composites with Epoxy and Elium© Based Matrices
(2023-12-12)In recent years, there has been a gradual surge in the demand for fiber-reinforced plastics (FRPs). The implementation of FRPs can be observed across nearly every industry, ranging from advanced applications in aviation ... -
Characterization of the mechanical and hormonal sensitivity of glutamate receptor subtype expression on murine osteoclasts.
(Dalhousie University, 2005) -
Characterization of the mitochondrial genome and ribosomal RNAs of the colorless green alga Polytomella parva.
(Dalhousie University, 2002) -
CHARACTERIZATION OF THE PHOSPHODIESTERASE SUBTYPES THAT REGULATE MOUSE ATRIAL MYOCYTE ELECTROPHYSIOLOGY
(2012-11-20)Phosphodiesterases (PDEs) are the enzymes responsible for the hydrolysis of cyclic nucleotides including cAMP and cGMP. We recently discovered that natriuretic peptides elicit effects in the atrial myocardium via a PDE ... -
Characterization of the potato late blight pathogen (Phytophthora infestans) in Canada and its implications on disease management and fungicide resistance
(2024-07-10)Late blight, caused by Phytophthora infestans, poses a major threat to potato and tomato crops globally. In Canada, increased incidence and severity of late blight have coincided with shifts in the genetic makeup of P. ... -
Characterization of the roles of neuronal cholesterol biosynthesis and ORP4 in hippocampal neurons and glia
(2018-01-05)Cholesterol is an essential component of cell membranes and plays important roles in cell signalling. The brain contains a quarter of the body’s total cholesterol pool, all of which is synthesized in situ by neurons and ... -
Characterization of The Viable but Non-Culturable Legionella pneumophila in Water and the Role of 3-Hydroxybutyrate Dehydrogenase in Its Formation
(2013-10-03)Legionella pneumophila, the causative agent of Legionnaires’ disease (LD), is an intracellular pathogen of freshwater protozoa that can also persist in the environment as a free-living bacterium. L. pneumophila has many ... -
Characterization of the virulence-related roles of the Legionella pneumophila chaperonin, HtpB, in mammalian cells.
(Dalhousie University, 2007) -
The Characterization of TiC and Ti(C,N) Based Cermets with and without Mo2C
(2014-03-05)Titanium carbide (TiC) and titanium carbonitride (Ti(C,N)) are both common components in hard, wear resistant ceramic-metal composites, or cermets. In this study the intermetallic nickel aluminide (Ni3Al) has been used as ... -
CHARACTERIZING A ROLE FOR NOS1AP IN CELLULAR MECHANOTRANSDUCTION
(2021-08-27)In a screen for proteins that interact with the phosphotyrosine binding (PTB) domain of NOS1AP we identified the b-integrin family of proteins. Fibronectin stimulated mouse embryonic fibroblasts (MEFs) from NOS1AP-/- mice ...