Browsing Faculty of Graduate Studies Online Theses by Title
Now showing items 1815-1834 of 7892
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The discovery of a novel series of amyloid-β antiaggregants based on the structure of 3-hydroxyanthranilic acid: a detailed analysis of the mechanism of action underpinning antiaggregant activity
(2015-05-01)Alzheimer’s disease (AD) is the fourth leading cause of death in the industrialized nations, yet there are no disease-stabilizing therapies currently in use. The amyloid hypothesis suggests that oligomeric species of the ... -
Discovery of small molecule interactors of human ArfGAP1 and their potential use for the treatment of Parkinson’s disease
(2023-12-12)Parkinson’s disease (PD), a movement disorder affecting primarily elderly patients, is the second most common neurodegenerative disease. The majority of cases are idiopathic, however, a subset of patients have genetic ... -
Discrimination Learning Between and Within Complex Displays
(1970-09)The present experiment was designed to investigate discrimination learning between and within complex displays in a concept formation task. The displays were characterized by the presence or absence of a distinctive feature ... -
Discrimination of vaccine preventable serotypes of Streptococcus pneumoniae by PCR and sequencing
(2017-07-13)Streptococcus pneumoniae is a bacterium that causes significant morbidity and mortality worldwide, and vaccines have been developed against a certain number of its serotypes. Serotyping of S. pneumoniae is important to ... -
Discriminative Shape Feature Pooling in Deep Convolutional Networks for Visual Classification
(2016-12-12)Unlike conventional handcrafted feature extractors, deep learning approach can extract generic image features without relying on explicit domain knowledge. Recently, there is a trend of combining handcrafted features with ... -
Discussions of abnormality and deformity in early modern England, with particular reference to the notion of monstrosity.
(Dalhousie University, 1995) -
Disease-causing Mutations in Human Enzymes of the CDP-Ethanolamine and CDP-Choline Pathways Cause Distinct Growth and Phospholipid Synthesis Phenotypes in Saccharomyces cerevisiae
(2020-08-27)Phosphatidylcholine and phosphatidylethanolamine are two of the most abundant phospholipids present in eukaryotic cells. In mammalian cells, these are mainly synthesized through the Kennedy pathways. PCYT1A is the gene ... -
The diseases of listening in early modern England.
(Dalhousie University, 2003) -
DISMANTLING THE GREEN MACHINE: A CRITICAL REFLECTION ON TECHNOLOGY AND ECOMODERN ENVIRONMENTAL POLICY
(2020-08-28)Addressing the scale of negative environmental changes from the rapid expansion of human populations and economic growth is a critical policy issue in the twenty-first century. Government and corporate responses are directed ... -
Disordered Eating Behaviour and Depressive Symptoms Among Nova Scotia Youth
(2011-12-15)Prevalence rates for adolescent depressive symptoms differ significantly between males and females. Explanatory models are unable to adequately clarify why this difference exists. To enhance understanding of gender ... -
Disorienting Responsibility
(2012-09-11)Experiences of disorientation can be common and powerful parts of moral agents' lives yet they have not been characterized by mainstream Western philosophers, and their effects have not been adequately ... -
Dispatch Policies between Hubs in the Physical Internet with Emission Considerations and Local Dispatch Using Machine Learning
(2023-12-15)This thesis presents a comprehensive analysis of dispatch management in Physical Internet (PI) logistics systems. As a modular approach to freight deliveries and container transportation, it aims to reduce costs and ... -
Dispersal, homing, and connectivity in the estuarine fish, Osmerus mordax.
(Dalhousie University, 2007) -
DISPERSION MODELING OF OXIDES OF NITROGEN, SULFUR DIOXIDE AND PM2.5 IN THE PROVINCE OF NOVA SCOTIA, CANADA
(2011-11-09)This study focuses on NOx, PM2.5 and SO2 dispersion modeling in seven domains across the province of Nova Scotia. The emission sources of the above pollutants include major industrial sources and highways across the province. ... -
Dispersive Effects of the Stress-optic Response in Oxide Glasses
(2010-06-22)Anisotropy in glass can lead to a transmitted double image due to birefringence. Stress-induced birefringence, the stress-optic effect, is undesirable for applications such as commercial imaging. The leading zero stress-optic ... -
Displaced Women: Stitching Through Transitional Period Beyond Liminality
(2024-07-12)Women during and post-displacement are the most vulnerable to violence and at risk of their livelihood. It has become common for individuals and communities to experience more than one displacement in their lifespan, ... -
Disputed Sovereignty: A Bilateral Solution to the Northwest Passage
(2010-09-20)This study examines how the legal dispute between Canada and the United States, on the status of the Northwest Passage could be resolved through diplomatic means. It asserts that Canada is unable to unilaterally defend its ... -
DISRUPTION OF SLEEP AND CIRCADIAN RHYTHM ORGANIZATION AS RISK FACTORS FOR DIAGNOSIS OF ALZHEIMER’S DISEASE
(2016-08-26)Individuals commonly report disrupted nighttime sleep and daytime sleepiness in the early, preclinical, stages of Alzheimer’s disease (AD), as well as other dementias. Furthermore, there is accumulating evidence of a ... -
Dissecting Co-management - An Examination of Fishermen Involvement in Fisheries Management in Nova Scotia, Canada
(2017-05-02)This research provides a systematic assessment of fishermen involvement, by first disaggregating fisheries management into its various components, allowing for a more nuanced understanding of the realities of co-management, ... -
Dissecting Race: An Examination of Anatomical Illustration and the Absence of Non-White Bodies
(2015)This thesis is an examination of representations of non-white bodies in the anatomical illustrations used in biomedical pedagogical literature. Particular attention has been paid in recent years to the lack of female ...