NSIS Volume 43, Part 2
http://hdl.handle.net/10222/70956
2024-03-28T19:59:42ZNSIS Presidential Address and Reports from Council Officers, Session 2004-2005
http://hdl.handle.net/10222/72689
NSIS Presidential Address and Reports from Council Officers, Session 2004-2005
Nova Scotian Institute of Science
Title includes: PRESIDENT'S REPORT; LIBRARIAN'S REPORT; EDITOR'S REPORT; TREASURER'S REPORT; and AUDITORS' REPORT.
2006-01-01T00:00:00ZRATIONAL DRUG DESIGN: A WINDOW INTO THE AMBITIOUS QUEST OF A NEUROLOGIST AND CHEMIST
http://hdl.handle.net/10222/72688
RATIONAL DRUG DESIGN: A WINDOW INTO THE AMBITIOUS QUEST OF A NEUROLOGIST AND CHEMIST
PATERSON, JENNIFER
In the difficult world of drug discovery, two main courses of action are open: one is to
screen extensive libraries of chemical compounds against hundreds of disease models;
another is to acquire a detailed understanding of the molecules involved in a particular
disease, and then rationally design compounds that can interact with or block those
molecules. The first approach is favoured by large pharmaceutical companies, while
the second is favoured by academics. This article illustrates the pursuit of this second
approach by a Dalhousie University neurologist and chemist. Through interviews with
this scientist and several of his colleagues, the article reveals the science of rational
drug design, as well as some of the challenges and compromises involved in bringing
discoveries to comm.ercial stages.
2005 NSIS Scientific Writing Award
2006-01-01T00:00:00ZDESIGN STUDY OF NOVEL LIGHT GUIDE GEOMETRY FOR SCINTILLATION COUNTERS
http://hdl.handle.net/10222/72687
DESIGN STUDY OF NOVEL LIGHT GUIDE GEOMETRY FOR SCINTILLATION COUNTERS
GLISTER, JACKIE; SARTY, ADAM J.
Two scintillating panels (S1 and S2) have been used as triggers in the high resolution
spectrometers in HallAofthe Thomas Jefferson NationalAccelerator Facility. New panels
are to be installed in place of S1 and S2 and it was proposed that the currently used
90° twisted light guides be replaced by a new adiabatic S-shape design (2 or 3 strips).
Using CERN's Guide7, Monte Carlo simulations were performed on four different light
guide geometries: rectangular, standard fishtail, 2-strip S-shape and 3-strip S-shape.
It was found that the two S-shape designs gave roughly 2x improvement on collection
efficiency and 1.2-1 .4x improvement on time resolution oversimple designs (rectangular
and fishtail). The 3-strip S-shape guide (90 pico-second time resolution and a 30%
collection efficiency) was recommended for replacement of the twisted shape; actual
experimental comparisons are also advised.
2005 NSIS Undergraduate Student Prize Winning Paper in the Physical Sciences
2006-01-01T00:00:00ZGROWTH AND PHENYLALANINE AMMONIA LYASE ACTIVITY OF Rhodotorula g/utinis: OPTIMIZATION OF CONDITIONS FOR THE SYNTHESIS OF L-PHENYLALANINE
http://hdl.handle.net/10222/72686
GROWTH AND PHENYLALANINE AMMONIA LYASE ACTIVITY OF Rhodotorula g/utinis: OPTIMIZATION OF CONDITIONS FOR THE SYNTHESIS OF L-PHENYLALANINE
WALL, MARK; D'CUNHA, GODWIN
A procedure is described for the synthesis of L-phenylalanine from trans-cinnamic
acid and ammonia utilizing the reverse reaction of phenylalanine ammonia lyase (PAL)
from Rhodotoru/a glutinis. Optimal conditions determined for yeast growth and PAL
production were pH 6, 1% inoculum, 30°C for 26-28 h. Optimization of conditions for
maximal phenylalanine production included incubation time (16 -18 h), temperature
(30°C), pH (9 .0), selected concentrations of substrates: 0.1 M trans-cinnamic acid and
4.0M NH40H and 0.1M Tris-HCI. Under these conditions about 85% conversion of
substrate to product was obtained.
2005 NSIS Undergraduate Student Prize Winning Paper in the Life Sciences
2006-01-01T00:00:00Z