Browsing by Subject "anoikis"
Now showing items 1-3 of 3
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Oncogenic ras-induced downregulation of a pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells
(Journal of Biological Chemistry, 2011-11-11)Resistance of carcinoma cells to anoikis, apoptosis that is normally induced by loss of cell-to-extracellular matrix (ECM) adhesion, is thought to be essential for the ability of these cells to form primary tumors, invade ... -
Regulation of Programmed Cell Death and Lipid Droplet Formation by CTP:Phosphocholine Cytidylyltransferase Alpha (CCTα)
(2016-01-14)Phosphatidylcholine (PtdCho), the most abundant phospholipid in eukaryotic cell membranes, is synthesized by the CDP-choline pathway under the control of the rate-limiting nuclear enzyme CTP:phosphocholine cytidylyltransferase ... -
Tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells
(International Journal of Cancer, 2011-11-02)Resistance of carcinoma cells to anoikis, apoptosis that is normally induced by detachment of non-malignant epithelial cells from the extracellular matrix, is thought to be critical for carcinoma progression. Molecular ...