Browsing by Subject "Catalysis"
Now showing items 1-12 of 12
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Advances in Nickel-Catalyzed C-N Cross-Coupling Enabled by Tailored Ancillary Ligand Design
(2018-12-05)The nickel-catalyzed Csp2-N cross-coupling of NH substrates and (hetero)aryl (pseudo)halides for the synthesis of (hetero)anilines is in the midst of a resurgence. Reactivity breakthroughs that have been achieved in this ... -
Exploring Ligand-Enabled Nickel-Catalyzed Cross-Coupling of Sulfur-Based Nucleophiles
(2022-12-12)The catalytic synthesis of C(sp2)-N linkages is of utmost significance in modern synthetic chemistry, predominantly due to their prevalence in active pharmaceutical ingredients and natural products. Pd-catalyzed cross-couplings ... -
Exploring the Catalytic Radical Reactivity of Diazaphospholenes
(2021-12-16)A subset of N-heterocyclic phosphines known as 1,3,2 diazaphospholenes (DAPs) have amassed significant attention over recent years. DAPs are excellent reduction catalysts for carbonyls, imines, pyridines, and enoates by ... -
N-Phosphinoamidinate Nickel Complexes
(2021-01-07)Society demands cheaper and more abundant metal catalysts to accomplish the tasks previously performed by precious metal catalysts. In turn, chemists have developed ancillary ligands designed to harness the power of first-row ... -
The Pursuit of Effective Catalysis for C-C and C-N Cross-Coupling under Mild Conditions
(2018-04-03)Homogeneous transition metal-catalysis has had a great impact on the synthesis of organic molecules in recent years. The selective mono-arylation of small molecules, a class of reactions predominantly achieved via transition ... -
Small Molecule Activation Facilitated by Main Group Elements
(2021-08-30)Main group containing systems are emerging as an alternative to transition metal catalysts, often showing complementary reactivity. Transition metal complexes have provided the basis for fascinating catalytic reactions ... -
Studies on Ligand Binding and Catalysis by Isoleucine Epimerase and CTP Synthase
(2023-06-13)Isoleucine 2-epimerase participates in production of branched-chain D-amino acids. We showed that L- and D-neopentyl glycine are substrates of LbIleE, with Km values of 0.65 ± 0.03 mM and 0.43 ± 0.03 mM, respectively. The ... -
Synthesis and Catalytic Ability of Diazaphospholenes
(2018-04-02)This thesis presents a facile entry into diazaphospholene catalysis, harnessing pre- catalysts formed through the reaction of diazaphospholene-bromide compounds with neopentyl alcohol, to afford crystalline pre-catalysts. ... -
Synthesis and Catalytic Activity of 1,2,4,3-Triazaphospholenes
(2018-04-04)Catalysis plays a key role in the industrial production of many refined goods. Catalysts derived from precious metals are especially prevalent in industry due to their high stereoselectivity, and low loadings. To alleviate ... -
Synthesis and Study of New Late Metal Complexes Featuring N-Phosphinoamidinate Ligands
(2017-12-12)N-Phosphinoamidine/amidinate (P,N) ligands have recently been shown to be highly effective for the selective chromium-catalyzed tri-/tetramerization of ethylene. Since this initial report, a joint collaboration between the ... -
Synthesis of (Phosphino)silyl-Ligated Nickel Complexes for the Catalytic Hydroboration of Alkenes
(2022-08-30)Bis(phosphino)silyl (PSiP) pincer ligands have been studied extensively. While there are several examples of late transition metal complexes, in recent years there has been a shift to study these ligands on first-row ... -
Synthesis of Diazaphospholenes for Improved Catalysis
(2023-08-28)Diazaphospholene (DAP) synthesis and reactivity has been emerging over the last two decades. Recently, DAPs have been employed as catalysts for asymmetric reduction transformations. Specifically in the Speed group we use ...