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Now showing items 34545-34564 of 38058
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Synthesis of (Phosphino)silyl-Ligated Nickel Complexes for the Catalytic Hydroboration of Alkenes
(2022-08-30)Bis(phosphino)silyl (PSiP) pincer ligands have been studied extensively. While there are several examples of late transition metal complexes, in recent years there has been a shift to study these ligands on first-row ... -
The synthesis of 1,2-bis(4’-(triazenyl)phenyl)ethanes
(1995)A series of1,2·bis-(4'-(triazenyl)phenyl)ethanes (2) has been synthesised by bis-diazotization of ethylene dianiline, and coupling of the resulting bis-diazonium salt with appropriate alkyl or dialkylamines. The bis-triazenes ... -
Synthesis of 2-aryl Pyrroles, Prodigiosene F-BODIPYs and B-ring Modified Prodigiosenes
(2019-12-16)Pyrrole constitutes the structural backbone of many natural products including heme and prodigiosin. This tripyrrolic natural product, and its synthetic analogues termed prodigiosenes, are reported to have an impressive ... -
Synthesis of a Glycosidase Inhibitor and a Potential Phosphoglucomutase Inhibitor, Expression of the Corresponding Proteins, and their Evaluation Using Kinetics or 19F-NMR Spectroscopy
(2019-11-28)The inhibition and reactivation of several naturally prevalent enzymes has many pharmaceutical applications. A glycosidase inhibitor, 2,4-dinitrophenyl 2-deoxy-2-fluoro-β-D-glucopyranose (6), was synthesized and its kinetics ... -
Synthesis of a novel fluorinated phosphonyl C-glycoside, (3-deoxy-3-fluoro- F β-d-glucopyranosyl)methylphosphonate, a potential inhibitor of β- phosphoglucomutase Postprint
(Elsevier, 2023)β-phosphoglucomutase (βPGM) catalyzes the conversion of β-glucose 1-phosphate (βG1P) to glucose-6-phosphate (G6P), a universal source of cellular energy, in a two-step process. Transition state analogue (TSA) complexes ... -
Synthesis of a novel glycodendrimer based on pentaerythritol and some chemistry of dipentaerythritol and tripentaerythritol.
(Dalhousie University, 2005) -
Synthesis of Co and Ni Complexes for Stereoselective Hydrogenation Catalysis
(2023-06-08)The chemistry of PSiP pincer complexes of second- and third-row transition metals has been well established within the context of bond activation chemistry and catalysis. Recent developments have begun to establish the ... -
Synthesis of Diazaphospholenes for Improved Catalysis
(2023-08-28)Diazaphospholene (DAP) synthesis and reactivity has been emerging over the last two decades. Recently, DAPs have been employed as catalysts for asymmetric reduction transformations. Specifically in the Speed group we use ... -
Synthesis of dipyrrins bearing chirality adjacent to the conjugated skeleton - Electron-poor pyrroles exhibit dramatically reduced nucleophilicity
(2008-10)With the aim of furthering our investigations into the asymmetric complexation of dipyrrinato ligands, a dipyrrin bearing a stereogenic centre directly adjacent to the conjugated skeleton was synthesized. The electron- ... -
Synthesis of Heterocycles via Chemoselective Geminal Acylation of 2-Methoxyoxazolidines, E/Z Isomerization in the Metathesis of Allyl Alcohol Derivatives with a First-Generation Ruthenium Catalyst, and Interception of Nazarov Reaction Intermediates of Allenyl Vinyl Ketones with Arenes
(2013-10-11)Heterocycles were prepared through the geminal acylation of 2-methoxyoxazolidines with 1,2-bis(trimethylsilyloxy)cyclobutene. It was found that when water was excluded from the standard reaction conditions, regioselectivity ... -
Synthesis of heteroleptic pyrrolide/bipyridyl complexes of ruthenium(II)
(2012-08)The synthesis and characterization of the first heteroleptic pyrrolide/2,2'-bipyridyl complexes of ruthenium(II) are reported. Pyrroles substituted at the 2-position with X = O functionality react with Ru(bipy)(2)Cl-2.2H(2)O ... -
Synthesis of natural products containing the pyrrolic ring
(2010)This review provides an overview of the synthetic chemistry that has been utilised to prepare natural products containing a pyrrolic ring. -
Synthesis of Novel Types of Polyester Glycodendrimers and the Development and Applications of an Efficient Alternative to Multistep Regioselective Esterification in Diols and Polyols
(2016-01-19)Polyester dendrimers are attractive for biological applications because they are biodegradable and non-toxic. The preparation of a variety of core molecules that are compatible with deprotection using hydrogenolysis is ... -
The Synthesis of Prodigiosene-Based Anticancer Reagents and Development of Reactions for Dipyrrin-Based Molecules
(2017-08-22)Prodigiosenes, dipyrrins and F-BODIPYs are related pyrrolic compounds that share a common, conjugated backbone structure composed of an adhered pyrrole and azafulvene unit. Prodigiosenes are tripyrrolic compounds isolated ... -
Synthesis of Prodigiosene-Estrogen Conjugates: optimization of protecting group strategies and anticancer properties
(Canadian Journal of Chemistry, 2015)The tripyrrolic prodigiosene skeleton was conjugated to several estrogen ligands. The conjugation was achieved via an ester linker that proved to be unusually sensitive to hydrolysis during synthesis. This work describes ... -
Synthesis of segments of the repeating unit of the C-polysaccharide of Streptococcus pneumoniae.
(Dalhousie University, 2005) -
Synthesis of some neutral and acidic zona pellucida oligosaccharides.
(Dalhousie University, 2003)
