| dc.contributor.author | Miller, J. D. (J. David) | |
| dc.contributor.author | Savard, M.E. | |
| dc.date.accessioned | 2013-08-08T18:30:53Z | |
| dc.date.available | 2013-08-08T18:30:53Z | |
| dc.date.issued | 1991-02 | |
| dc.identifier.citation | Miller, J.D., and M.E. Savard. "Antibiotic activity of the marine fungus Leptosphaeria oraemaris." Proceedings of the Nova Scotian Institute of Science. 39.2 (1991): 51-58. Print. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10222/35250 | |
| dc.description | Includes b&w illus.; bibliographic references | en_US |
| dc.description.abstract | Two new pigments, obioninene and oraemarin from the lignicolous marine fungus Leptosphaeria
oraemaris are described. The effect of salinity on the production of antibiotic compounds from this
organism was investigated. Activity of extracts in the HeLa cell bioassay was greatest for fermentations
of lower salinity. Toxicity of extracts to brine shrimp larvae was greatest at 14, 18 and 22‰. In contrast,
activity against a marine bacterium was greatest in extracts from fermentations from higher salinities
(>26‰). The results are discussed in relation to the ecology of L oraemaris. | en_US |
| dc.description.abstract | Deux nouveaux pigments, I'obioninene et I'oraemarin, oblenus du fungus marin lignicole Leptosphaeria oraemaris, sont décrits. L'effet de la salinité sur la production de composés antibiotiques par cet organisme a été étudié. L'activité biologique, telle que mesurée par la toxicté envers les cellules HeLa, fut inversement proportionnelle à Ia salinité de la fermentation. La toxidté des extra its envers les larves de crevettes de mer fut plus élevée à 14, 18 et 22‰. Par contre, I'activite contre une bacterie fut plus elevee pour les fermentations a haute salinite (> 26‰). Les résultats sont discutés en de I'écologie de L. oraemaris. | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Dalhousie Printing Centre | en_US |
| dc.subject | Marine fungi | |
| dc.subject | Antibiotic-producing organisms | |
| dc.title | Antibiotic activity of the marine fungus Leptosphaeria oraemaris. | en_US |
| dc.type | Article | en_US |
