Pharmacy: Recent submissions

Now showing items 21-24 of 24

  • Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates 

    Huestis, Malcolm P.; Aish, Gaia A.; Hui, Joseph P. M.; Soo, Evelyn C.; Jakeman, David L. (2008-02)
    Structure-based design of alkyl sugar-1-phosphates provides an efficient nucleotidylyltransferase-catalyzed synthesis of a series of new lipophilic sugar nucleotides possessing long or branched alkyl chains, thereby ...

  • Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans 

    Syvitski, Raymond T.; Tian, Xiao-Lin; Sampara, Kamal; Salman, Alan; Lee, Song F.; Jakeman, David L.; Li, Yung-Hua (2007-02)
    Streptococcus mutans secretes and utilizes a 21-amino-acid signaling peptide pheromone to initiate quorum sensing for genetic competence, biofilm formation, stress responses, and bacteriocin production. In this study, we ...

  • Antimicrobial Activities of Jadomycin B and Structurally Related Analogues 

    Jakeman, David L.; Bandi, Srinivasulu; Graham, Cathy L.; Reid, Taryn R.; Wentzell, Jason R.; Douglas, Susan E. (2009-03)
    Natural products are leads for new antibiotics as a result of their structural complexity and diversity. We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ...

  • Drug Use Management and Policy Residency: A Service-Learning Application 

    Conrad, Patricia; Murphy, Joseph; Sketris, Ingrid S. (American Journal of Pharmaceutical Education, 2005)
    Objectives. To establish, implement, and evaluate a drug use management and policy residency program within the context of a service-learning framework. Design. Residents completed a 4-month term in which they were ...