Browsing by Subject "Pharmacology"
Now showing items 1-17 of 17
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THE ANTICANCER ACTIVITY AND MECHANISMS OF ACTION OF JADOMYCINS IN MULTIDRUG RESISTANT HUMAN BREAST CANCER CELLS
(2018-09-28)Breast cancer is the most common cancer in women, and approximately one third of all breast cancers will ultimately metastasize. Metastatic breast cancer is classified as an incurable disease. The development of multidrug ... -
Biased Agonists and Allosteric Modulators of the Type 1 Cannabinoid Receptor: Potential Treatments for Huntington Disease
(2016-04-05)Huntington disease (HD) is caused by the inheritance of a single copy of the mutant huntingtin gene. HD patients suffer from progressive cognitive decline, psychoses, depression, an inability to gain and maintain weight, ... -
CANNABINOIDS REGULATE TYPE 1 CANNABINOID RECEPTOR EXPRESSION IN CELL CULTURE MODELS OF HUNTINGTON'S DISEASE
(2012-08-10)Type 1 cannabinoid receptor (CB1) levels decline in the striatum of animal models of Huntington’s disease (HD) and in the brains of human patients suffering from HD prior to other pathogenic changes. CB1 levels can be ... -
DRUG USE AND AGE ALTERS THE DRUG METABOLISM POTENTIAL OF THE HUMAN GUT MICROBIOME
(2016-08-23)While drugs play an important role in human health, the interaction between the human microbiome and the metabolism of drugs remains relatively unknown. Studies have demonstrated the microbiome's capability to metabolize ... -
The edema of para-phenylenediamine
(Wm. Macnab & Son, 1930) -
The effect of velocity on diffusion rates
(Wm. Macnab & Son, 1928) -
An electronic perfusion pump, with especial reference to its use of blood-flow
(Wm. Macnab & Son, 1927) -
GENETIC VARIANTS OF ERYTHROPOIETIN AND THEIR BIOLOGICAL SIGNIFICANCE
(2023-08-16)Erythropoietin (EPO) is a hematopoietic cytokine with a multitude of functions, that are erythropoietic, metabolic or cytoprotective. The erythropoietic functions of EPO have led to the development of many erythropoietic ... -
Intestinal reaction to drugs in different fishes
(Wm. Macnab & Son, 1928) -
Investigating the FDA's Appraisal of Preclinical Studies in New Drug Applications for Pain Indications and its Implications for Pepducin P4pal-10
(2023-08-28)Musculoskeletal diseases are responsible for a large proportion of disabling conditions, with chronic pain being the primary concern for patients. Current drug options are limited and often associated with adverse side ... -
The measurement of renal blood-flow in the fowl
(Wm. Macnab & Son, 1927) -
A new method of measuring blood-flow (a demonstration of the apparatus)
(Wm. Macnab & Son, 1928) -
A note on the biological assay of tincture digitalis
(Wm. Macnab & Son, 1930) -
Nova Scotia Medical Bulletin 25(12), 1946
(Medical Society of Nova Scotia, 1946) -
On the distribution of quinine in the blood
(Wm. Macnab & Son, 1927) -
PHARMACOLOGICAL MANIPULATION OF MICROGLIA TO SUPPRESS NEUROINFLAMMATION AND PROTECT NEURONS
(2023-08-30)Microglia are the resident immune cells of the brain that survey the microenvironment, provide trophic support to neurons, and clear debris to maintain homeostasis and healthy brain function. Microglia are also drivers of ... -
The Role of Adrenergic Receptor Signaling in Embryonic Ventricular Cell Proliferation and Differentiation
(2019-11-28)In the adult heart, cardiomyocytes (CM) that die in response to aging or pathological insults are replaced by scar tissue. Transplantation of embryonic cardiac progenitor cells (CPC) was shown to increase the contractile ...