Browsing by Subject "Neurodegeneration"
Now showing items 1-5 of 5
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Characterization of the Diet-Microbiota-Gut-Brain Axis and its Role in Neuroinflammation
(2022-09-01)Neurodegenerative Diseases (NDs) are the leading causes of disability/death globally. The Diet-Microbiota-Gut-Brain (DMGB) axis is a promising area of research for NDs, investigating how intercommunication between diet, ... -
Clinicopathological Correlates in Tauopathy and Aging
(2022-08-16)Cognitive decline can result from both neurodegenerative or normal aging processes. Definitive diagnosis of many neurodegenerative diseases, such as Alzheimer’s disease (AD) and progressive supranuclear palsy (PSP), requires ... -
EXPLORING THE ROLE OF MITOCHONDRIAL CHOLESTEROL IN NIEMANN-PICK TYPE C DISEASE
(2016-01-19)Niemann-Pick type C (NPC) disease is an autosomal recessive neurodegenerative disorder caused by mutations in Npc1 or Npc2 gene. Npc1 and Npc2 encode a late-endosomal transmembrane and lumenal cholesterol-binding domain ... -
A Novel Model of Elevated Mitochondrial Cholesterol and The Consequences for Mitochondrial Function
(2020-09-11)Increased mitochondrial cholesterol may induce mitochondrial dysfunction and play a role in the progression of neurodegenerative disease and cancer. The voltage-dependent anion channel of the outer mitochondrial membrane ... -
TRPML1 in Autophagy and Neuromuscular Diseases
(2023-08-31)Autophagy is a process that maintains cellular homeostasis and monitors nutrient requirements. During autophagy, cytoplasmic components are engulfed by autophagosomes. These autophagosomes fuse with lysosomes, where lysosomal ...